N-[(S)-5-((S)-1-{(S)-1-[(S)-5-Benzyloxycarbonylamino-1-((1S,2R)-2-hydroxy-indan-1-ylcarbamoyl)-pentylcarbamoyl]-2-phenyl-ethylcarbamoyl}-2-phenyl-ethylcarbamoyl)-5-tert-butoxycarbonylamino-pentyl]-succinamic acid

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Chemical Name:N-[(S)-5-((S)-1-{(S)-1-[(S)-5-Benzyloxycarbonylamino-1-((1S,2R)-2-hydroxy-indan-1-ylcarbamoyl)-pentylcarbamoyl]-2-phenyl-ethylcarbamoyl}-2-phenyl-ethylcarbamoyl)-5-tert-butoxycarbonylamino-pentyl]-succinamic acid
CAS No.:215512-32-6
Molecular Formula:C₅₆H₇₁N₇O₁₂
Molecular Weight:1034.22
Hs Code.:

N-[(S)-5-((S)-1-{(S)-1-[(S)-5-Benzyloxycarbonylamino-1-((1S,2R)-2-hydroxy-indan-1-ylcarbamoyl)-pentylcarbamoyl]-2-phenyl-ethylcarbamoyl}-2-phenyl-ethylcarbamoyl)-5-tert-butoxycarbonylamino-pentyl]-succinamic acid

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Chemical Property of N-[(S)-5-((S)-1-{(S)-1-[(S)-5-Benzyloxycarbonylamino-1-((1S,2R)-2-hydroxy-indan-1-ylcarbamoyl)-pentylcarbamoyl]-2-phenyl-ethylcarbamoyl}-2-phenyl-ethylcarbamoyl)-5-tert-butoxycarbonylamino-pentyl]-succinamic acid

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Technology Process of N-[(S)-5-((S)-1-{(S)-1-[(S)-5-Benzyloxycarbonylamino-1-((1S,2R)-2-hydroxy-indan-1-ylcarbamoyl)-pentylcarbamoyl]-2-phenyl-ethylcarbamoyl}-2-phenyl-ethylcarbamoyl)-5-tert-butoxycarbonylamino-pentyl]-succinamic acid

There total 2 articles about N-[(S)-5-((S)-1-{(S)-1-[(S)-5-Benzyloxycarbonylamino-1-((1S,2R)-2-hydroxy-indan-1-ylcarbamoyl)-pentylcarbamoyl]-2-phenyl-ethylcarbamoyl}-2-phenyl-ethylcarbamoyl)-5-tert-butoxycarbonylamino-pentyl]-succinamic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 215512-31-5
[(S)-1-((S)-1-{(S)-1-[(S)-5-Benzyloxycarbonylamino-1-((1S,2R)-2-hydroxy-indan-1-ylcarbamoyl)-pentylcarbamoyl]-2-phenyl-ethylcarbamoyl}-2-phenyl-ethylcarbamoyl)-5-(9H-fluoren-9-ylmethoxycarbonylamino)-pentyl]-carbamic acid tert-butyl ester

: 215512-32-6
N-[(S)-5-((S)-1-{(S)-1-[(S)-5-Benzyloxycarbonylamino-1-((1S,2R)-2-hydroxy-indan-1-ylcarbamoyl)-pentylcarbamoyl]-2-phenyl-ethylcarbamoyl}-2-phenyl-ethylcarbamoyl)-5-tert-butoxycarbonylamino-pentyl]-succinamic acid

Guidance literature:: Multi-step reaction with 2 steps

1: Et₂NH / dimethylformamide

2: iPr₂NEt / dimethylformamide

With diethylamine; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide;
DOI:10.1016/S0223-5234(98)80043-3

Reference yield:

: 108-30-5
succinic acid anhydride

: [(S)-5-Amino-1-((S)-1-{(S)-1-[(S)-5-benzyloxycarbonylamino-1-((1S,2R)-2-hydroxy-indan-1-ylcarbamoyl)-pentylcarbamoyl]-2-phenyl-ethylcarbamoyl}-2-phenyl-ethylcarbamoyl)-pentyl]-carbamic acid tert-butyl ester

: 215512-32-6
N-[(S)-5-((S)-1-{(S)-1-[(S)-5-Benzyloxycarbonylamino-1-((1S,2R)-2-hydroxy-indan-1-ylcarbamoyl)-pentylcarbamoyl]-2-phenyl-ethylcarbamoyl}-2-phenyl-ethylcarbamoyl)-5-tert-butoxycarbonylamino-pentyl]-succinamic acid

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide;
DOI:10.1016/S0223-5234(98)80043-3

Reference yield:

: 215512-32-6
N-[(S)-5-((S)-1-{(S)-1-[(S)-5-Benzyloxycarbonylamino-1-((1S,2R)-2-hydroxy-indan-1-ylcarbamoyl)-pentylcarbamoyl]-2-phenyl-ethylcarbamoyl}-2-phenyl-ethylcarbamoyl)-5-tert-butoxycarbonylamino-pentyl]-succinamic acid

: 215511-39-0
[(2S,5S,8S,23S)-2,5-Dibenzyl-8-((1S,2R)-2-hydroxy-indan-1-ylcarbamoyl)-3,6,14,17,24-pentaoxo-1,4,7,13,18-pentaaza-cyclotetracos-23-yl]-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: H₂ / Pd/C

2: BOP, NaHCO₃ / dimethylformamide / Ambient temperature

With hydrogen; sodium hydrogencarbonate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; palladium on activated charcoal; In N,N-dimethyl-formamide;
DOI:10.1016/S0223-5234(98)80043-3