C₂₇H₂₉N₅O₄

Base Information

• Chemical Name: C₂₇H₂₉N₅O₄
• CAS No.: 1374220-12-8
• Molecular Formula: C₂₇H₂₉N₅O₄
• Molecular Weight: 487.558
• Mol file: 1374220-12-8.mol

Synonyms:

Chemical Property of C₂₇H₂₉N₅O₄

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₇H₂₉N₅O₄

There total 5 articles about C₂₇H₂₉N₅O₄ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-(1,3-dihydro-4-phenyl-2(2H)-oxoimidazol-1-yl)piperidine (205058-28-2) → C27H29N5O4 (1374220-12-8)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine; 3-[(diethoxyphosphinyl)oxy]-1,2,3-benzotriazin-4(3H)-one / dichloromethane

2: lithium hydroxide / tetrahydrofuran

With triethylamine; 3-[(diethoxyphosphinyl)oxy]-1,2,3-benzotriazin-4(3H)-one; lithium hydroxide; In tetrahydrofuran; dichloromethane;

DOI:10.1016/j.bmcl.2012.02.066

Reference yield:

7-methyl-1H-indazole-5-carbaldehyde (635712-40-2) → C27H29N5O4 (1374220-12-8)

Guidance literature:

Multi-step reaction with 4 steps

1: potassium tert-butylate / tert-butyl alcohol

2: palladium on activated charcoal; hydrogen / methanol; ethyl acetate

3: triethylamine; 3-[(diethoxyphosphinyl)oxy]-1,2,3-benzotriazin-4(3H)-one / dichloromethane

4: lithium hydroxide / tetrahydrofuran

With palladium on activated charcoal; potassium tert-butylate; hydrogen; triethylamine; 3-[(diethoxyphosphinyl)oxy]-1,2,3-benzotriazin-4(3H)-one; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate; tert-butyl alcohol; 1: Stobbe condensation;

DOI:10.1016/j.bmcl.2012.02.066

Reference yield:

C28H31N5O4 (1374219-98-3) → C27H29N5O4 (1374220-12-8)

Guidance literature:

With lithium hydroxide; In tetrahydrofuran;

DOI:10.1016/j.bmcl.2012.02.066

upstream raw materials:

4-(1,3-dihydro-4-phenyl-2(2H)-oxoimidazol-1-yl)piperidine

7-methyl-1H-indazole-5-carbaldehyde

2-(7-methyl-1H-indazol-5-ylmethylene)-succinic acid 1-methyl ester

(+/-)-2-(7-Methyl-1H-indazol-5-ylmethyl)-succinic acid 1-methyl ester

Downstream raw materials:

C₃₇H₄₇N₇O₃