Technology Process of 3-iodo-2-phenylpyridine
There total 3 articles about 3-iodo-2-phenylpyridine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
3-amino-2-phenylpyridine;
With
toluene-4-sulfonic acid;
In
acetonitrile;
at 10 - 15 ℃;
Inert atmosphere;
With
potassium iodide; sodium nitrite;
In
water; acetonitrile;
at 10 - 20 ℃;
for 1.16667h;
Inert atmosphere;
DOI:10.1055/s-0031-1289652
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: palladium 10% on activated carbon; hydrogen / tetrahydrofuran / 16 h / 20 °C / Inert atmosphere
2.1: toluene-4-sulfonic acid / acetonitrile / 10 - 15 °C / Inert atmosphere
2.2: 1.17 h / 10 - 20 °C / Inert atmosphere
With
palladium 10% on activated carbon; hydrogen; toluene-4-sulfonic acid;
In
tetrahydrofuran; acetonitrile;
2.1: Sandmeyer reaction / 2.2: Sandmeyer reaction;
DOI:10.1055/s-0031-1289652
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: palladium 10% on activated carbon; sodium carbonate; triphenylphosphine / 1,2-dimethoxyethane / 80 °C / Inert atmosphere
2.1: palladium 10% on activated carbon; hydrogen / tetrahydrofuran / 16 h / 20 °C / Inert atmosphere
3.1: toluene-4-sulfonic acid / acetonitrile / 10 - 15 °C / Inert atmosphere
3.2: 1.17 h / 10 - 20 °C / Inert atmosphere
With
palladium 10% on activated carbon; hydrogen; sodium carbonate; toluene-4-sulfonic acid; triphenylphosphine;
In
tetrahydrofuran; 1,2-dimethoxyethane; acetonitrile;
1.1: Suzuki coupling / 3.1: Sandmeyer reaction / 3.2: Sandmeyer reaction;
DOI:10.1055/s-0031-1289652
