2-[2-(4,4-dimethyl-3-phenyl-pent-1-ynyl)-phenylethynyl]-2'-methoxy-[1,1']binaphthalenyl

Base Information

Chemical Name:2-[2-(4,4-dimethyl-3-phenyl-pent-1-ynyl)-phenylethynyl]-2'-methoxy-[1,1']binaphthalenyl
CAS No.:909022-88-4
Molecular Formula:C₄₂H₃₄O
Molecular Weight:554.731
Hs Code.:

Synonyms:

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Chemical Property of 2-[2-(4,4-dimethyl-3-phenyl-pent-1-ynyl)-phenylethynyl]-2'-methoxy-[1,1']binaphthalenyl

Chemical Property:

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Technology Process of 2-[2-(4,4-dimethyl-3-phenyl-pent-1-ynyl)-phenylethynyl]-2'-methoxy-[1,1']binaphthalenyl

There total 10 articles about 2-[2-(4,4-dimethyl-3-phenyl-pent-1-ynyl)-phenylethynyl]-2'-methoxy-[1,1']binaphthalenyl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 891199-67-0,909101-69-5,909101-70-8
2-ethynyl-2'methoxy-1,1'-binaphthyl

: 909022-88-4
2-[2-(4,4-dimethyl-3-phenyl-pent-1-ynyl)-phenylethynyl]-2'-methoxy-[1,1']binaphthalenyl

Guidance literature:: Multi-step reaction with 4 steps

1.1: 90 percent / copper(I) iodide; diisopropylamine / Pd(PPh₃)4 / toluene / 13 h / 70 °C

2.1: 94 percent / sodium hydroxide / diethyl ether; methanol / 0.5 h / 20 °C

3.1: n-butyllithium / diethyl ether; hexane / 0.5 h / 0 °C

3.2: 92 percent / diethyl ether; hexane / 2 h / 20 °C

4.1: 89 percent / triethylsilane; trifluoroacetic acid / CH₂Cl₂ / 0.08 h / 20 °C

With triethylsilane; sodium hydroxide; copper(l) iodide; n-butyllithium; diisopropylamine; trifluoroacetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In methanol; diethyl ether; hexane; dichloromethane; toluene; 1.1: Sonogashira reaction;
DOI:10.1016/j.tet.2006.06.004

Reference yield:

: 38274-16-7
2-bromo-1-(trimethylsilylethynyl)benzene

: 909022-88-4
2-[2-(4,4-dimethyl-3-phenyl-pent-1-ynyl)-phenylethynyl]-2'-methoxy-[1,1']binaphthalenyl

Guidance literature:: Multi-step reaction with 5 steps

1.1: n-butyllithium / tetrahydrofuran / -78 °C

1.2: iodine / tetrahydrofuran

2.1: 90 percent / copper(I) iodide; diisopropylamine / Pd(PPh₃)4 / toluene / 13 h / 70 °C

3.1: 94 percent / sodium hydroxide / diethyl ether; methanol / 0.5 h / 20 °C

4.1: n-butyllithium / diethyl ether; hexane / 0.5 h / 0 °C

4.2: 92 percent / diethyl ether; hexane / 2 h / 20 °C

5.1: 89 percent / triethylsilane; trifluoroacetic acid / CH₂Cl₂ / 0.08 h / 20 °C

With triethylsilane; sodium hydroxide; copper(l) iodide; n-butyllithium; diisopropylamine; trifluoroacetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; diethyl ether; hexane; dichloromethane; toluene; 2.1: Sonogashira reaction;
DOI:10.1016/j.tet.2006.06.004

Reference yield:

: 35193-70-5
2-hydroxy-2'-methoxy-1,1'-binaphthyl

: 909022-88-4
2-[2-(4,4-dimethyl-3-phenyl-pent-1-ynyl)-phenylethynyl]-2'-methoxy-[1,1']binaphthalenyl

Guidance literature:: Multi-step reaction with 9 steps

1.1: 91 percent / pyridine

2.1: 93 percent / NiCl₂(dppp)

3.1: 90 percent / NBS; AIBN

4.1: 86 percent / NaIO₄

5.1: 90 percent / potassium carbonate / methanol / 24 h / 20 °C

6.1: 90 percent / copper(I) iodide; diisopropylamine / Pd(PPh₃)4 / toluene / 13 h / 70 °C

7.1: 94 percent / sodium hydroxide / diethyl ether; methanol / 0.5 h / 20 °C

8.1: n-butyllithium / diethyl ether; hexane / 0.5 h / 0 °C

8.2: 92 percent / diethyl ether; hexane / 2 h / 20 °C

9.1: 89 percent / triethylsilane; trifluoroacetic acid / CH₂Cl₂ / 0.08 h / 20 °C

With pyridine; triethylsilane; sodium hydroxide; sodium periodate; N-Bromosuccinimide; copper(l) iodide; n-butyllithium; 2,2'-azobis(isobutyronitrile); potassium carbonate; diisopropylamine; trifluoroacetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 1,3-bis[(diphenylphosphino)propane]dichloronickel(II); In methanol; diethyl ether; hexane; dichloromethane; toluene; 6.1: Sonogashira reaction;
DOI:10.1016/j.tet.2006.06.004