2-methoxy-2'-[2-[(trimethylsilyl)ethynyl]phenyl]-ethynyl-1,1'-binaphthyl

Base Information

Chemical Name:2-methoxy-2'-[2-[(trimethylsilyl)ethynyl]phenyl]-ethynyl-1,1'-binaphthyl
CAS No.:909022-85-1
Molecular Formula:C₃₄H₂₈OSi
Molecular Weight:480.681
Hs Code.:

Synonyms:2-methoxy-2'-[2-[(trimethylsilyl)ethynyl]phenyl]-ethynyl-1,1'-binaphthyl

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Chemical Property of 2-methoxy-2'-[2-[(trimethylsilyl)ethynyl]phenyl]-ethynyl-1,1'-binaphthyl

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Technology Process of 2-methoxy-2'-[2-[(trimethylsilyl)ethynyl]phenyl]-ethynyl-1,1'-binaphthyl

There total 7 articles about 2-methoxy-2'-[2-[(trimethylsilyl)ethynyl]phenyl]-ethynyl-1,1'-binaphthyl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 891199-67-0,909101-69-5,909101-70-8
2-ethynyl-2'methoxy-1,1'-binaphthyl

: 137648-47-6
1-iodo-2-ethynylbenzene

: 909022-85-1
2-methoxy-2'-[2-[(trimethylsilyl)ethynyl]phenyl]-ethynyl-1,1'-binaphthyl

Guidance literature:: With copper(l) iodide; diisopropylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In toluene; at 70 ℃; for 13h;
DOI:10.1016/j.tet.2006.06.004

Reference yield:

: 38274-16-7
2-bromo-1-(trimethylsilylethynyl)benzene

: 909022-85-1
2-methoxy-2'-[2-[(trimethylsilyl)ethynyl]phenyl]-ethynyl-1,1'-binaphthyl

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium / tetrahydrofuran / -78 °C

1.2: iodine / tetrahydrofuran

2.1: 90 percent / copper(I) iodide; diisopropylamine / Pd(PPh₃)4 / toluene / 13 h / 70 °C

With copper(l) iodide; n-butyllithium; diisopropylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; toluene; 2.1: Sonogashira reaction;
DOI:10.1016/j.tet.2006.06.004

Reference yield:

: 35193-70-5
2-hydroxy-2'-methoxy-1,1'-binaphthyl

: 909022-85-1
2-methoxy-2'-[2-[(trimethylsilyl)ethynyl]phenyl]-ethynyl-1,1'-binaphthyl

Guidance literature:: Multi-step reaction with 6 steps

1: 91 percent / pyridine

2: 93 percent / NiCl₂(dppp)

3: 90 percent / NBS; AIBN

4: 86 percent / NaIO₄

5: 90 percent / potassium carbonate / methanol / 24 h / 20 °C

6: 90 percent / copper(I) iodide; diisopropylamine / Pd(PPh₃)4 / toluene / 13 h / 70 °C

With pyridine; sodium periodate; N-Bromosuccinimide; copper(l) iodide; 2,2'-azobis(isobutyronitrile); potassium carbonate; diisopropylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 1,3-bis[(diphenylphosphino)propane]dichloronickel(II); In methanol; toluene; 6: Sonogashira reaction;
DOI:10.1016/j.tet.2006.06.004