(2-{(4S,6S)-6-[(4R,6R)-6-(2-Benzyloxy-ethyl)-2,2-dimethyl-[1,3]dioxan-4-ylmethyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-ethoxy)-tert-butyl-diphenyl-silane

Base Information

Chemical Name:(2-{(4S,6S)-6-[(4R,6R)-6-(2-Benzyloxy-ethyl)-2,2-dimethyl-[1,3]dioxan-4-ylmethyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-ethoxy)-tert-butyl-diphenyl-silane
CAS No.:127723-94-8
Molecular Formula:C₄₀H₅₆O₆Si
Molecular Weight:660.967
Hs Code.:

(2-{(4S,6S)-6-[(4R,6R)-6-(2-Benzyloxy-ethyl)-2,2-dimethyl-[1,3]dioxan-4-ylmethyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-ethoxy)-tert-butyl-diphenyl-silane

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Chemical Property of (2-{(4S,6S)-6-[(4R,6R)-6-(2-Benzyloxy-ethyl)-2,2-dimethyl-[1,3]dioxan-4-ylmethyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-ethoxy)-tert-butyl-diphenyl-silane

Chemical Property:

Purity/Quality:

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Technology Process of (2-{(4S,6S)-6-[(4R,6R)-6-(2-Benzyloxy-ethyl)-2,2-dimethyl-[1,3]dioxan-4-ylmethyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-ethoxy)-tert-butyl-diphenyl-silane

There total 23 articles about (2-{(4S,6S)-6-[(4R,6R)-6-(2-Benzyloxy-ethyl)-2,2-dimethyl-[1,3]dioxan-4-ylmethyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-ethoxy)-tert-butyl-diphenyl-silane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 125975-53-3,147220-48-2,116996-54-4
(2S)-O-(tert-butyldiphenylsilyl)-1,2-epoxybutan-4-ol

: 127723-94-8,127760-87-6
(2-{(4S,6S)-6-[(4R,6R)-6-(2-Benzyloxy-ethyl)-2,2-dimethyl-[1,3]dioxan-4-ylmethyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-ethoxy)-tert-butyl-diphenyl-silane

Guidance literature:: Multi-step reaction with 10 steps

2: 97 percent / n-BuLi / tetrahydrofuran / -78 °C

3: 76 percent / n-BuLi, HMPA / tetrahydrofuran / -78 °C

4: aq. AcOH

5: CSA / CH₂Cl₂ / Ambient temperature

6: NBS, AgNO₃, 2,6-lutidine / acetonitrile; H₂O

7: 80 percent / K₂CO₃ / methanol

8: DIBAH / toluene / -48 °C

9: NaH / tetrahydrofuran

10: n-Bu₃SnH, AlBN / toluene / Heating

With 2,6-dimethylpyridine; N,N,N,N,N,N-hexamethylphosphoric triamide; N-Bromosuccinimide; n-butyllithium; 2,2'-azobis(isobutyronitrile); camphor-10-sulfonic acid; tri-n-butyl-tin hydride; sodium hydride; diisobutylaluminium hydride; potassium carbonate; silver nitrate; acetic acid; In tetrahydrofuran; methanol; dichloromethane; water; toluene; acetonitrile;
DOI:10.1016/S0040-4039(01)89012-2

Reference yield:

: 100-39-0
benzyl bromide

: 127723-94-8,127760-87-6
(2-{(4S,6S)-6-[(4R,6R)-6-(2-Benzyloxy-ethyl)-2,2-dimethyl-[1,3]dioxan-4-ylmethyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-ethoxy)-tert-butyl-diphenyl-silane

Guidance literature:: Multi-step reaction with 11 steps

3: 98 percent / Et₃N / Ambient temperature

4: 74 percent / Et₃N

5: aq. AcOH

6: CSA / CH₂Cl₂

7: 52 percent / t-BuONa, KMnO₄ / 2-methyl-propan-2-ol

8: 80 percent / K₂CO₃ / methanol

9: DIBAH / toluene / -48 °C

10: NaH / tetrahydrofuran

11: n-Bu₃SnH, AlBN / toluene / Heating

With potassium permanganate; 2,2'-azobis(isobutyronitrile); camphor-10-sulfonic acid; tri-n-butyl-tin hydride; sodium hydride; diisobutylaluminium hydride; potassium carbonate; acetic acid; triethylamine; sodium t-butanolate; In tetrahydrofuran; methanol; dichloromethane; toluene; tert-butyl alcohol;
DOI:10.1016/S0040-4039(01)89012-2

Reference yield:

: 115114-87-9
(2R)-2-(2-benzyloxyethyl)oxirane

: 127723-94-8,127760-87-6
(2-{(4S,6S)-6-[(4R,6R)-6-(2-Benzyloxy-ethyl)-2,2-dimethyl-[1,3]dioxan-4-ylmethyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-ethoxy)-tert-butyl-diphenyl-silane

Guidance literature:: Multi-step reaction with 10 steps

2: 98 percent / Et₃N / Ambient temperature

3: 74 percent / Et₃N

4: aq. AcOH

5: CSA / CH₂Cl₂

6: 52 percent / t-BuONa, KMnO₄ / 2-methyl-propan-2-ol

7: 80 percent / K₂CO₃ / methanol

8: DIBAH / toluene / -48 °C

9: NaH / tetrahydrofuran

10: n-Bu₃SnH, AlBN / toluene / Heating

With potassium permanganate; 2,2'-azobis(isobutyronitrile); camphor-10-sulfonic acid; tri-n-butyl-tin hydride; sodium hydride; diisobutylaluminium hydride; potassium carbonate; acetic acid; triethylamine; sodium t-butanolate; In tetrahydrofuran; methanol; dichloromethane; toluene; tert-butyl alcohol;
DOI:10.1016/S0040-4039(01)89012-2