5'-(Bis-allyloxy-phosphoryl)-2',6'-dimethyl-2-methylsulfanyl-1',4'-dihydro-[3,4']bipyridinyl-3'-carboxylic acid 2-(benzyl-methyl-amino)-ethyl ester

Base Information

• Chemical Name: 5'-(Bis-allyloxy-phosphoryl)-2',6'-dimethyl-2-methylsulfanyl-1',4'-dihydro-[3,4']bipyridinyl-3'-carboxylic acid 2-(benzyl-methyl-amino)-ethyl ester
• CAS No.: 104246-14-2
• Molecular Formula: C₃₀H₃₈N₃O₅PS
• Molecular Weight: 583.689

Synonyms:

Chemical Property of 5'-(Bis-allyloxy-phosphoryl)-2',6'-dimethyl-2-methylsulfanyl-1',4'-dihydro-[3,4']bipyridinyl-3'-carboxylic acid 2-(benzyl-methyl-amino)-ethyl ester

Chemical Property:

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Technology Process of 5'-(Bis-allyloxy-phosphoryl)-2',6'-dimethyl-2-methylsulfanyl-1',4'-dihydro-[3,4']bipyridinyl-3'-carboxylic acid 2-(benzyl-methyl-amino)-ethyl ester

There total 4 articles about 5'-(Bis-allyloxy-phosphoryl)-2',6'-dimethyl-2-methylsulfanyl-1',4'-dihydro-[3,4']bipyridinyl-3'-carboxylic acid 2-(benzyl-methyl-amino)-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

2-ethyl 3-aminocrotonate (54527-73-0) + {1-[1-(2-Methylsulfanyl-pyridin-3-yl)-meth-(Z)-ylidene]-2-oxo-propyl}-phosphonic acid diallyl ester (112057-48-4,112076-53-6) → 5'-(Bis-allyloxy-phosphoryl)-2',6'-dimethyl-2-methylsulfanyl-1',4'-dihydro-[3,4']bipyridinyl-3'-carboxylic acid 2-(benzyl-methyl-amino)-ethyl ester (104246-14-2)

Guidance literature:

In isopropyl alcohol; Heating;

DOI:10.1248/cpb.35.3898

Reference yield:

2-Methylthiopyridine-3-carbaldehyde (62658-92-8) → 5'-(Bis-allyloxy-phosphoryl)-2',6'-dimethyl-2-methylsulfanyl-1',4'-dihydro-[3,4']bipyridinyl-3'-carboxylic acid 2-(benzyl-methyl-amino)-ethyl ester (104246-14-2)

Guidance literature:

Multi-step reaction with 2 steps

1: piperidine-AcOH salt / benzene / Heating

2: 47 percent / propan-2-ol / Heating

With piperdinium acetate; In isopropyl alcohol; benzene;

DOI:10.1248/cpb.35.3898

Reference yield:

triallyl phosphite (102-84-1) → 5'-(Bis-allyloxy-phosphoryl)-2',6'-dimethyl-2-methylsulfanyl-1',4'-dihydro-[3,4']bipyridinyl-3'-carboxylic acid 2-(benzyl-methyl-amino)-ethyl ester (104246-14-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 51 percent / 120 °C

2: piperidine-AcOH salt / benzene / Heating

3: 47 percent / propan-2-ol / Heating

With piperdinium acetate; In isopropyl alcohol; benzene;

DOI:10.1248/cpb.35.3898

upstream raw materials:

2-ethyl 3-aminocrotonate

{1-[1-(2-Methylsulfanyl-pyridin-3-yl)-meth-(Z)-ylidene]-2-oxo-propyl}-phosphonic acid diallyl ester

2-Methylthiopyridine-3-carbaldehyde

triallyl phosphite

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