5-chloro-2,3-dimethoxyphenylacetohydroxamic acid

Base Information

• Chemical Name: 5-chloro-2,3-dimethoxyphenylacetohydroxamic acid
• CAS No.: 86232-45-3
• Molecular Formula: C₁₀H₁₂ClNO₄
• Molecular Weight: 245.663
• Mol file: 86232-45-3.mol

Synonyms:

Chemical Property of 5-chloro-2,3-dimethoxyphenylacetohydroxamic acid

Chemical Property:

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-chloro-2,3-dimethoxyphenylacetohydroxamic acid

There total 15 articles about 5-chloro-2,3-dimethoxyphenylacetohydroxamic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

methyl 5-chloro-2,3-dimethoxyphenylacetate (86232-43-1) → 5-chloro-2,3-dimethoxyphenylacetohydroxamic acid (86232-45-3)

Guidance literature:

With hydroxylamine; In methanol; for 6h; Heating;

Reference yield:

5-chloro-2-hydroxy-3-methoxy-benzaldehyde (7740-05-8) → 5-chloro-2,3-dimethoxyphenylacetohydroxamic acid (86232-45-3)

Guidance literature:

Multi-step reaction with 8 steps

1: 1) 99percent hydrazine hydrate, 2) KOH / 1) reflux, 5 h, 2) reflux, 5 h

2: 75 percent / K₂CO₃ / acetone / 5 h / Heating

3: 77 percent / KMnO₄ / H₂O / 5 h / Heating

4: SOCl₂ / 2 h / Heating

5: diethyl ether / 10 h / 20 °C

6: 45 percent / silver oxide / dioxane; H₂O / 1 h / 95 °C

7: 71 percent / conc. H₂SO₄ / 1,2-dichloro-ethane / 15 h / Heating

8: 74 percent / NH₂OH / methanol / 6 h / Heating

With potassium hydroxide; potassium permanganate; thionyl chloride; sulfuric acid; hydroxylamine; potassium carbonate; hydrazine hydrate; silver(l) oxide; In 1,4-dioxane; methanol; diethyl ether; water; 1,2-dichloro-ethane; acetone;

Reference yield:

3-methoxy-2-hydroxybenzaldehyde (148-53-8) → 5-chloro-2,3-dimethoxyphenylacetohydroxamic acid (86232-45-3)

Guidance literature:

Multi-step reaction with 9 steps

1: 45 percent / chlorine / acetic acid / 5 h / 20 °C

2: 1) 99percent hydrazine hydrate, 2) KOH / 1) reflux, 5 h, 2) reflux, 5 h

3: 75 percent / K₂CO₃ / acetone / 5 h / Heating

4: 77 percent / KMnO₄ / H₂O / 5 h / Heating

5: SOCl₂ / 2 h / Heating

6: diethyl ether / 10 h / 20 °C

7: 45 percent / silver oxide / dioxane; H₂O / 1 h / 95 °C

8: 71 percent / conc. H₂SO₄ / 1,2-dichloro-ethane / 15 h / Heating

9: 74 percent / NH₂OH / methanol / 6 h / Heating

With potassium hydroxide; potassium permanganate; thionyl chloride; sulfuric acid; hydroxylamine; chlorine; potassium carbonate; hydrazine hydrate; silver(l) oxide; In 1,4-dioxane; methanol; diethyl ether; water; acetic acid; 1,2-dichloro-ethane; acetone;

upstream raw materials:

methyl 5-chloro-2,3-dimethoxyphenylacetate

5-chloro-2-hydroxy-3-methoxy-benzaldehyde

5-chloro-2,3-dimethoxybenzaldehyde

3-Methyl-4,5-dimethoxyaniline