4-[3-(2-{2-(tert-butyl-dimethyl-silanyloxy)-2-[3-(thiophene-2-sulfonylamino)-phenyl]-ethylamino}-propyl)-1H-indol-7-yloxysulfonyl]-benzoic acid ethyl ester

Base Information

Chemical Name:4-[3-(2-{2-(tert-butyl-dimethyl-silanyloxy)-2-[3-(thiophene-2-sulfonylamino)-phenyl]-ethylamino}-propyl)-1H-indol-7-yloxysulfonyl]-benzoic acid ethyl ester
CAS No.:820216-59-9
Molecular Formula:C₃₈H₄₇N₃O₈S₃Si
Molecular Weight:798.09
Hs Code.:

4-[3-(2-{2-(<i>tert</i>-butyl-dimethyl-silanyloxy)-2-[3-(thiophene-2-sulfonylamino)-phenyl]-ethylamino}-propyl)-1<i>H</i>-indol-7-yloxysulfonyl]-benzoic acid ethyl ester

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Chemical Property of 4-[3-(2-{2-(tert-butyl-dimethyl-silanyloxy)-2-[3-(thiophene-2-sulfonylamino)-phenyl]-ethylamino}-propyl)-1H-indol-7-yloxysulfonyl]-benzoic acid ethyl ester

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Technology Process of 4-[3-(2-{2-(tert-butyl-dimethyl-silanyloxy)-2-[3-(thiophene-2-sulfonylamino)-phenyl]-ethylamino}-propyl)-1H-indol-7-yloxysulfonyl]-benzoic acid ethyl ester

There total 10 articles about 4-[3-(2-{2-(tert-butyl-dimethyl-silanyloxy)-2-[3-(thiophene-2-sulfonylamino)-phenyl]-ethylamino}-propyl)-1H-indol-7-yloxysulfonyl]-benzoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 244081-35-4
(R)-3-(2-aminopropyl)-7-benzyloxyindole

: 820216-59-9
4-[3-(2-{2-(tert-butyl-dimethyl-silanyloxy)-2-[3-(thiophene-2-sulfonylamino)-phenyl]-ethylamino}-propyl)-1H-indol-7-yloxysulfonyl]-benzoic acid ethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 97 percent / CHCl₃

2: 99 percent / HCO₂NH₄ / Pd/C / methanol

3: TEA / CH₂Cl₂

4: 98 percent / WSC; DMAP / CH₂Cl₂

5: HCl / ethyl acetate

6: i-PrNEt₂; KI / acetonitrile

With hydrogenchloride; dmap; N,N-diethyl-N-isopropylamine; TEA; ammonium formate; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; potassium iodide; palladium on activated charcoal; In methanol; dichloromethane; chloroform; ethyl acetate; acetonitrile;
DOI:10.1016/j.bmcl.2004.10.035

Reference yield:

: 244081-38-7
(2R)-7-benzyloxy-3-[2-(tert-butoxycarbonylamino)propyl]-1H-indole

: 820216-59-9
4-[3-(2-{2-(tert-butyl-dimethyl-silanyloxy)-2-[3-(thiophene-2-sulfonylamino)-phenyl]-ethylamino}-propyl)-1H-indol-7-yloxysulfonyl]-benzoic acid ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 99 percent / HCO₂NH₄ / Pd/C / methanol

2: TEA / CH₂Cl₂

3: 98 percent / WSC; DMAP / CH₂Cl₂

4: HCl / ethyl acetate

5: i-PrNEt₂; KI / acetonitrile

With hydrogenchloride; dmap; N,N-diethyl-N-isopropylamine; TEA; ammonium formate; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; potassium iodide; palladium on activated charcoal; In methanol; dichloromethane; ethyl acetate; acetonitrile;
DOI:10.1016/j.bmcl.2004.10.035

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 820216-59-9
4-[3-(2-{2-(tert-butyl-dimethyl-silanyloxy)-2-[3-(thiophene-2-sulfonylamino)-phenyl]-ethylamino}-propyl)-1H-indol-7-yloxysulfonyl]-benzoic acid ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: imidazole / dimethylformamide

2: aq. NH₄Cl; Fe / ethanol

3: pyridine / CH₂Cl₂

4: i-PrNEt₂; KI / acetonitrile

With pyridine; 1H-imidazole; N,N-diethyl-N-isopropylamine; iron; ammonium chloride; potassium iodide; In ethanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.bmcl.2004.10.035