N-{[4,5-bis-(4-methoxy-phenyl)-2-oxo-oxazol-3-yl]-acetyl}-L-tryptophyl->L-methionyl->L-α-aspartyl->L-phenylalanine amide

Base Information

• Chemical Name: N-{[4,5-bis-(4-methoxy-phenyl)-2-oxo-oxazol-3-yl]-acetyl}-L-tryptophyl->L-methionyl->L-α-aspartyl->L-phenylalanine amide
• CAS No.: 66851-74-9
• Molecular Formula: C₄₈H₅₁N₇O₁₁S
• Molecular Weight: 934.039
• Mol file: 66851-74-9.mol

Synonyms:

Chemical Property of N-{[4,5-bis-(4-methoxy-phenyl)-2-oxo-oxazol-3-yl]-acetyl}-L-tryptophyl->L-methionyl->L-α-aspartyl->L-phenylalanine amide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-{[4,5-bis-(4-methoxy-phenyl)-2-oxo-oxazol-3-yl]-acetyl}-L-tryptophyl->L-methionyl->L-α-aspartyl->L-phenylalanine amide

There total 2 articles about N-{[4,5-bis-(4-methoxy-phenyl)-2-oxo-oxazol-3-yl]-acetyl}-L-tryptophyl->L-methionyl->L-α-aspartyl->L-phenylalanine amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

[4,5-bis-(4-methoxy-phenyl)-2-oxo-oxazol-3-yl]-acetic acid (66851-61-4) → N-{[4,5-bis-(4-methoxy-phenyl)-2-oxo-oxazol-3-yl]-acetyl}-L-tryptophyl->L-methionyl->L-α-aspartyl->L-phenylalanine amide (66851-74-9)

Guidance literature:

Multi-step reaction with 2 steps

1: DCC / tetrahydrofuran / 0 °C

2: (i) PhOMe, CF₃CO₂H, (ii) /BRN= 1060838/, Et₃N, DMF

With dicyclohexyl-carbodiimide; In tetrahydrofuran;

DOI:10.1248/cpb.26.660

Reference yield:

[4,5-bis-(4-methoxy-phenyl)-2-oxo-oxazol-3-yl]-acetic acid 4-nitro-phenyl ester (66851-73-8) + N-tert-butoxycarbonyl-L-tryptophyl->L-methionyl->L-α-aspartyl->L-phenylalanine amide (5235-21-2) → N-{[4,5-bis-(4-methoxy-phenyl)-2-oxo-oxazol-3-yl]-acetyl}-L-tryptophyl->L-methionyl->L-α-aspartyl->L-phenylalanine amide (66851-74-9)

Guidance literature:

Multistep reaction; (i) PhOMe, CF₃CO₂H, (ii) /BRN= 1060838/, Et₃N, DMF;

DOI:10.1248/cpb.26.660

upstream raw materials:

[4,5-bis-(4-methoxy-phenyl)-2-oxo-oxazol-3-yl]-acetic acid 4-nitro-phenyl ester

N-tert-butoxycarbonyl-L-tryptophyl->L-methionyl->L-α-aspartyl->L-phenylalanine amide

[4,5-bis-(4-methoxy-phenyl)-2-oxo-oxazol-3-yl]-acetic acid