5235-21-2

Usage

InChI:InChI=1/C7H14S3/c1-5-6(8)9-10-7(2,3)4/h5H2,1-4H3

Upstream product

• 3392-11-8 2,5-dioxopyrrolidin-1-yl N-(tert-butoxycarbonyl)-L-tryptophanate 
• 63229-05-0 L-Methionyl-L-aspartyl-L-phenylalanine amide trifluoroacetate 
• 16948-13-3 Boc-Met-OTcp 
• 5241-71-4 Asp-Phe-NH₂ 
• 5241-58-7 L-Phenylalanine amide 
• 123197-15-9 Boc-Trp-Met-Asp-OH 
• 103802-00-2 Boc-Met-Asp-OH 
• 15160-31-3 (tert-butyloxycarbonyl)-l-tryptophan p-nitrophenyl ester 
• 5920-14-9 N^α-tert-Butyloxycarbonyl-L-methionyl-L-aspartyl-L-phenylalanine amide 
• 50903-55-4 pentafluorophenyl ester of N^α-tert-butoxycarbonyl-L-tryptophan 

Downstream Products

• 5549-48-4 H-Trp-Met-Asp-Phe-NH₂*TFA 
• 5609-49-4 L-Tryptophyl-L-methionyl-L-aspartyl-L-phenylalanine amide hydrochloride 
• 66851-74-9 N-{[4,5-bis-(4-methoxy-phenyl)-2-oxo-oxazol-3-yl]-acetyl}-L-tryptophyl->L-methionyl->L-α-aspartyl->L-phenylalanine amide 

Relevant academic research and scientific papers

PAPAIN-CATALYZED FRAGMENT SYNTHESIS OF PROTECTED CHOLECYSTOKININ DERIVATIVES

Sodium salts of methyl esters of N-tert-butyloxycarbonyl-β-tert-butylaspartyl-O4-sulfotyrosine (II) or N-tert-butyloxycarbonyl-O4-sulfotyrosine (III) were condensed with amino components derived from peptide amides IVb-IVe and IVg (simulating the carboxy-terminal part of cholecystokinin) under catalysis with papain.Rates and yields of conversion of these peptides to the corresponding derivatives Ib-If were compared with the results reported previously for analogous papain-catalyzed fragment synthesis of the protected carboxy-terminal octapeptide of cholecystokinin Ia.In the condensation reactions with the individual amino components quantitative changes were observed in the ability of papain to catalyze the peptide bond synthesis which appeared as differences in the maximum yield (and the time required for achieving it) of the condensation reaction, monitored by HLPC.The observed differences are related not only with the distance of the amino acid substitution from the P'1 subsite in the given amino component but also with the side-chain structure of the substituting amino acid.

α-AMINOACYL CONTAINING NEW PEPTIDES WITH GASTRIN EFFECTS AND A PROCESS FOR THE PREPARATION THEREOF

Peptides of the formula: wherein A is tert.-butoxycarbonyl-aminooxy-acyl, benzyloxycarbonyl-aminooxy-acyl, (aminooxy)-acyl, or E-aminooxy-acyl, wherein E is benzoyl or straight-chain or branched C1-5 aliphatic acyl, B is methionyl, leucyl, norleucyl, norvalyl or 2-amino-decanoyl, and Y is hydrogen or carboxymethoxy, and pharmaceutically acceptable acid-addition salts or complexes thereof have gastric-acid secretion increasing effects.