3'-O-acetyl-4-O-phenylthymidine

Base Information

• Chemical Name: 3'-O-acetyl-4-O-phenylthymidine
• CAS No.: 153434-31-2
• Molecular Formula: C₁₈H₂₀N₂O₆
• Molecular Weight: 360.367
• Mol file: 153434-31-2.mol

Synonyms:

Chemical Property of 3'-O-acetyl-4-O-phenylthymidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3'-O-acetyl-4-O-phenylthymidine

There total 1 articles about 3'-O-acetyl-4-O-phenylthymidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

acetic anhydride (108-24-7) + 4-O-phenyl-5'-O-(9-phenyl-9H-xanthen-9-yl)thymidine (92447-16-0) → 3'-O-acetyl-4-O-phenylthymidine (153434-31-2)

Guidance literature:

With dichloro-acetic acid; pyrrole; Yield given. Multistep reaction; 1.) pyridine, room temperature, 4 h, 2.) CH₂Cl₂, room temperature, 10 min;

Reference yield: 83.0%

4,6-dinitrobenzotriazol-3-ium-1-oxide (21047-77-8) + 3'-O-acetyl-4-O-phenylthymidine (153434-31-2) → 3'-O-acetyl-5'-O-(4,6-dinitrobenzotriazol-1-yl)-4-Ophenylthymidine + 4-O-phenyl-5'-O-(9-phenylxanthen-9-yl)thymidin-3'-yl 3'-O-acetyl-4-O-phenylthymidin-5'yl 2-chlorophenylphosphate

Guidance literature:

With 1-methyl-1H-imidazole; 4-O-phenyl-5'-O-(9-phenylxanthen-9-yl)thymidin-3'-yl 2-chlorophenyl hydrogen phosphate triethylammonium salt; 2-Nitrobenzenesulfonyl chloride; In pyridine; for 2h;

Reference yield: 67.0%

2-Nitrobenzenesulfonyl chloride (1694-92-4) + 3'-O-acetyl-4-O-phenylthymidine (153434-31-2) → 3'-O-acetyl-5'-O-(2-nitrophenylsulfonyl)-4-O-phenylthymidine + 4-O-phenyl-5'-O-(9-phenylxanthen-9-yl)thymidin-3'-yl 3'-O-acetyl-4-O-phenylthymidin-5'yl 2-chlorophenylphosphate

Guidance literature:

With 1-methyl-1H-imidazole; 4-O-phenyl-5'-O-(9-phenylxanthen-9-yl)thymidin-3'-yl 2-chlorophenyl hydrogen phosphate triethylammonium salt; 3-nitro-1,2,4-triazole; In pyridine; for 0.0333333h;

upstream raw materials:

acetic anhydride

4-O-phenyl-5'-O-(9-phenyl-9H-xanthen-9-yl)thymidine

Refernces