(S)-2-[(S)-2-(2-Acetylamino-acetylamino)-3-phenyl-propionylamino]-5-guanidino-pentanoic acid methyl ester; hydrochloride

Base Information

• Chemical Name: (S)-2-[(S)-2-(2-Acetylamino-acetylamino)-3-phenyl-propionylamino]-5-guanidino-pentanoic acid methyl ester; hydrochloride
• CAS No.: 82308-64-3
• Molecular Formula: C₂₀H₃₀N₆O₅*ClH
• Molecular Weight: 470.956
• Mol file: 82308-64-3.mol

Synonyms:

Chemical Property of (S)-2-[(S)-2-(2-Acetylamino-acetylamino)-3-phenyl-propionylamino]-5-guanidino-pentanoic acid methyl ester; hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-2-[(S)-2-(2-Acetylamino-acetylamino)-3-phenyl-propionylamino]-5-guanidino-pentanoic acid methyl ester; hydrochloride

There total 7 articles about (S)-2-[(S)-2-(2-Acetylamino-acetylamino)-3-phenyl-propionylamino]-5-guanidino-pentanoic acid methyl ester; hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C20H29N7O7 (85917-96-0) → (S)-2-[(S)-2-(2-Acetylamino-acetylamino)-3-phenyl-propionylamino]-5-guanidino-pentanoic acid methyl ester; hydrochloride (82308-64-3)

Guidance literature:

With hydrogenchloride; hydrogen; palladium dichloride; In methanol; Ambient temperature;

Reference yield:

N-tert-butoxycarbonyl-L-phenylalanine (13734-34-4) → (S)-2-[(S)-2-(2-Acetylamino-acetylamino)-3-phenyl-propionylamino]-5-guanidino-pentanoic acid methyl ester; hydrochloride (82308-64-3)

Guidance literature:

Multi-step reaction with 6 steps

1: N-methyl morpholine, isobutylchloroformate / dimethylformamide / 2 h / -50 °C

2: aq. HCl / ethyl acetate / 0.5 h / Ambient temperature

3: N-methyl morpholine, isobutylchloroformate / dimethylformamide / 2 h / -50 °C

4: aq. HCl / ethyl acetate / 0.5 h / Ambient temperature

5: 1.) triethylamine / dioxane / 1.) RT, 1 h, 2.) RT, 12 h

6: hydrogen, HCl / PdCl₂ / methanol / Ambient temperature

With 4-methyl-morpholine; hydrogenchloride; hydrogen; triethylamine; isobutyl chloroformate; palladium dichloride; In 1,4-dioxane; methanol; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

Boc-Phe-Arg(NO2)-OMe (26061-11-0) → (S)-2-[(S)-2-(2-Acetylamino-acetylamino)-3-phenyl-propionylamino]-5-guanidino-pentanoic acid methyl ester; hydrochloride (82308-64-3)

Guidance literature:

Multi-step reaction with 5 steps

1: aq. HCl / ethyl acetate / 0.5 h / Ambient temperature

2: N-methyl morpholine, isobutylchloroformate / dimethylformamide / 2 h / -50 °C

3: aq. HCl / ethyl acetate / 0.5 h / Ambient temperature

4: 1.) triethylamine / dioxane / 1.) RT, 1 h, 2.) RT, 12 h

5: hydrogen, HCl / PdCl₂ / methanol / Ambient temperature

With 4-methyl-morpholine; hydrogenchloride; hydrogen; triethylamine; isobutyl chloroformate; palladium dichloride; In 1,4-dioxane; methanol; ethyl acetate; N,N-dimethyl-formamide;

upstream raw materials:

C₂₀H₂₉N₇O₇

N-tert-butoxycarbonyl-L-phenylalanine

Boc-Phe-Arg(NO₂)-OMe

_N^ω-nitro-L-arginine methyl ester hydrochloride