6-nitro-2-phenyl chromene epoxide

Base Information

• Chemical Name: 6-nitro-2-phenyl chromene epoxide
• CAS No.: 1449311-86-7
• Molecular Formula: C₁₅H₁₁NO₄
• Molecular Weight: 269.257
• Mol file: 1449311-86-7.mol

Synonyms:

Chemical Property of 6-nitro-2-phenyl chromene epoxide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-nitro-2-phenyl chromene epoxide

There total 4 articles about 6-nitro-2-phenyl chromene epoxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6-nitro-2-phenyl-2H-chromene (121507-63-9) → 6-nitro-2-phenyl chromene epoxide (1449311-86-7) + 6-nitro-2-phenyl chromene epoxide

Guidance literature:

With tetraphenylphosphonium monoperoxysulfate; (+)-N-{(4S,5S)-2,2-dimethyl-4-[4-(methylsulfonyl)phenyl]-1,3-dioxan-5-yl}-3,4-dihydroisoquinolinium tetraphenylborate; In chloroform; at -30 ℃; for 0.166667h; Overall yield = 15%; Overall yield = 0.075 g;

DOI:10.1021/jo401345m

Reference yield:

3,3-diethoxyl-1-phenylprop-1-ene (7148-78-9) → 6-nitro-2-phenyl chromene epoxide (1449311-86-7) + 6-nitro-2-phenyl chromene epoxide

Guidance literature:

Multi-step reaction with 2 steps

1: 3-Methylpyridine / para-xylene / 24 h / Reflux; Inert atmosphere

2: (+)-N-{(4S,5S)-2,2-dimethyl-4-[4-(methylsulfonyl)phenyl]-1,3-dioxan-5-yl}-3,4-dihydroisoquinolinium tetraphenylborate; tetraphenylphosphonium monoperoxysulfate / chloroform / 0.17 h / -30 °C

With 3-Methylpyridine; tetraphenylphosphonium monoperoxysulfate; (+)-N-{(4S,5S)-2,2-dimethyl-4-[4-(methylsulfonyl)phenyl]-1,3-dioxan-5-yl}-3,4-dihydroisoquinolinium tetraphenylborate; In chloroform; para-xylene;

DOI:10.1021/jo401345m

Reference yield:

(E)-3-phenylpropenal (14371-10-9) → 6-nitro-2-phenyl chromene epoxide (1449311-86-7) + 6-nitro-2-phenyl chromene epoxide

Guidance literature:

Multi-step reaction with 3 steps

1: ammonium nitrate / 24 h / 20 °C / Molecular sieve; Inert atmosphere

2: 3-Methylpyridine / para-xylene / 24 h / Reflux; Inert atmosphere

3: (+)-N-{(4S,5S)-2,2-dimethyl-4-[4-(methylsulfonyl)phenyl]-1,3-dioxan-5-yl}-3,4-dihydroisoquinolinium tetraphenylborate; tetraphenylphosphonium monoperoxysulfate / chloroform / 0.17 h / -30 °C

With ammonium nitrate; 3-Methylpyridine; tetraphenylphosphonium monoperoxysulfate; (+)-N-{(4S,5S)-2,2-dimethyl-4-[4-(methylsulfonyl)phenyl]-1,3-dioxan-5-yl}-3,4-dihydroisoquinolinium tetraphenylborate; In chloroform; para-xylene;

DOI:10.1021/jo401345m

upstream raw materials:

6-nitro-2-phenyl-2H-chromene

3,3-diethoxyl-1-phenylprop-1-ene

(E)-3-phenylpropenal

4-nitro-phenol