tert-butyl 5-[(R)-[(2S,5R)-4-benzyl-2,5-dimethylpiperazinyl](3-methoxyphenyl)methyl]-1,3-dihydro-2H-isoindole-2-carboxylate

Base Information

• Chemical Name: tert-butyl 5-[(R)-[(2S,5R)-4-benzyl-2,5-dimethylpiperazinyl](3-methoxyphenyl)methyl]-1,3-dihydro-2H-isoindole-2-carboxylate
• CAS No.: 253801-16-0
• Molecular Formula: C₃₄H₄₃N₃O₃
• Molecular Weight: 541.734
• Mol file: 253801-16-0.mol

Synonyms:

Chemical Property of tert-butyl 5-[(R)-[(2S,5R)-4-benzyl-2,5-dimethylpiperazinyl](3-methoxyphenyl)methyl]-1,3-dihydro-2H-isoindole-2-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl 5-[(R)-[(2S,5R)-4-benzyl-2,5-dimethylpiperazinyl](3-methoxyphenyl)methyl]-1,3-dihydro-2H-isoindole-2-carboxylate

There total 2 articles about tert-butyl 5-[(R)-[(2S,5R)-4-benzyl-2,5-dimethylpiperazinyl](3-methoxyphenyl)methyl]-1,3-dihydro-2H-isoindole-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-formyl-1,2-dihydro-isoindole-2-carboxylic acid tertiary butyl ester (253801-15-9) + (3-methoxyphenyl)magnesium bromide (36282-40-3) + (-)-(2R,5S)-1-benzyl-2,5-dimethylpiperazine (216532-43-3,3138-88-3,324750-43-8,745031-35-0) → tert-butyl 5-[(R)-[(2S,5R)-4-benzyl-2,5-dimethylpiperazinyl](3-methoxyphenyl)methyl]-1,3-dihydro-2H-isoindole-2-carboxylate (253801-16-0)

Guidance literature:

5-formyl-1,2-dihydro-isoindole-2-carboxylic acid tertiary butyl ester; (-)-(2R,5S)-1-benzyl-2,5-dimethylpiperazine; With 1,2,3-Benzotriazole; In toluene; for 3h; Heating;

(3-methoxyphenyl)magnesium bromide; In tetrahydrofuran; toluene; at -20 - 20 ℃; for 1h; Further stages.;

DOI:10.1016/j.bmcl.2005.10.102

Reference yield:

→ tert-butyl 5-[(R)-[(2S,5R)-4-benzyl-2,5-dimethylpiperazinyl](3-methoxyphenyl)methyl]-1,3-dihydro-2H-isoindole-2-carboxylate (253801-16-0) + 5-[(R)-[(2S,5R)-4-benzyl-2,5-dimethylpiperazinyl](3-methoxyphenyl)methyl]isoindoline hydrochloride

Guidance literature:

Reference yield:

tert-butyl 5-[(R)-[(2S,5R)-4-benzyl-2,5-dimethylpiperazinyl](3-methoxyphenyl)methyl]-1,3-dihydro-2H-isoindole-2-carboxylate (253801-16-0) → C29H35N3O (253801-17-1)

Guidance literature:

With hydrogenchloride; In dichloromethane; at 0 ℃;

DOI:10.1016/j.bmcl.2005.10.102

upstream raw materials:

5-formyl-1,2-dihydro-isoindole-2-carboxylic acid tertiary butyl ester

(3-methoxyphenyl)magnesium bromide

(-)-(2R,5S)-1-benzyl-2,5-dimethylpiperazine

Downstream raw materials:

C₂₉H₃₅N₃O