Thioacetic acid S-((2R,3S,4R,5R)-5-(6-benzoylamino-purin-9-yl)-2-{2-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-ethyl}-4-hydroxy-tetrahydro-furan-3-ylmethyl) ester

Base Information

Chemical Name:Thioacetic acid S-((2R,3S,4R,5R)-5-(6-benzoylamino-purin-9-yl)-2-{2-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-ethyl}-4-hydroxy-tetrahydro-furan-3-ylmethyl) ester
CAS No.:1027944-33-7
Molecular Formula:C₄₂H₄₁N₅O₇S
Molecular Weight:759.883
Hs Code.:

Thioacetic acid S-((2R,3S,4R,5R)-5-(6-benzoylamino-purin-9-yl)-2-{2-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-ethyl}-4-hydroxy-tetrahydro-furan-3-ylmethyl) ester

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Chemical Property of Thioacetic acid S-((2R,3S,4R,5R)-5-(6-benzoylamino-purin-9-yl)-2-{2-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-ethyl}-4-hydroxy-tetrahydro-furan-3-ylmethyl) ester

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Technology Process of Thioacetic acid S-((2R,3S,4R,5R)-5-(6-benzoylamino-purin-9-yl)-2-{2-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-ethyl}-4-hydroxy-tetrahydro-furan-3-ylmethyl) ester

There total 6 articles about Thioacetic acid S-((2R,3S,4R,5R)-5-(6-benzoylamino-purin-9-yl)-2-{2-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-ethyl}-4-hydroxy-tetrahydro-furan-3-ylmethyl) ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 134056-17-0
(1R,5R,6R,7R)-6-<(benzoyloxy)methyl>-7-<<3-(trifluoromethyl)benzoyl>oxy>-2,8-dioxabicyclo<3.2.1>octane

: 1027944-33-7
Thioacetic acid S-((2R,3S,4R,5R)-5-(6-benzoylamino-purin-9-yl)-2-{2-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-ethyl}-4-hydroxy-tetrahydro-furan-3-ylmethyl) ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-methyl-N-trimethylsilyltrifluoroacetamide / acetonitrile / 0.25 h / 20 °C

1.2: 67 percent / trimethylsilyl triflate / acetonitrile / 45 h / 60 °C

2.1: triethylamine / tetrahydrofuran

3.1: 52 percent / NaOH / H₂O

4.1: Ph₃P; diisopropyl azodicarboxylate / tetrahydrofuran

With sodium hydroxide; di-isopropyl azodicarboxylate; N-methyl-N-trimethylsilyl-2,2,2-trifluoroacetamide; triethylamine; triphenylphosphine; In tetrahydrofuran; water; acetonitrile; 1.1: Vorbrueggen reaction / 4.1: Mitsunobu reaction;
DOI:10.1021/jo0003910

Reference yield:

: 4005-49-6
N-benzoyladenine

: 1027944-33-7
Thioacetic acid S-((2R,3S,4R,5R)-5-(6-benzoylamino-purin-9-yl)-2-{2-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-ethyl}-4-hydroxy-tetrahydro-furan-3-ylmethyl) ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-methyl-N-trimethylsilyltrifluoroacetamide / acetonitrile / 0.25 h / 20 °C

1.2: 67 percent / trimethylsilyl triflate / acetonitrile / 45 h / 60 °C

2.1: triethylamine / tetrahydrofuran

3.1: 52 percent / NaOH / H₂O

4.1: Ph₃P; diisopropyl azodicarboxylate / tetrahydrofuran

With sodium hydroxide; di-isopropyl azodicarboxylate; N-methyl-N-trimethylsilyl-2,2,2-trifluoroacetamide; triethylamine; triphenylphosphine; In tetrahydrofuran; water; acetonitrile; 1.1: Vorbrueggen reaction / 4.1: Mitsunobu reaction;
DOI:10.1021/jo0003910

Reference yield:

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 1027944-33-7
Thioacetic acid S-((2R,3S,4R,5R)-5-(6-benzoylamino-purin-9-yl)-2-{2-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-ethyl}-4-hydroxy-tetrahydro-furan-3-ylmethyl) ester

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / tetrahydrofuran

2: 52 percent / NaOH / H₂O

3: Ph₃P; diisopropyl azodicarboxylate / tetrahydrofuran

With sodium hydroxide; di-isopropyl azodicarboxylate; triethylamine; triphenylphosphine; In tetrahydrofuran; water; 3: Mitsunobu reaction;
DOI:10.1021/jo0003910