Technology Process of (2E,4E,6E)-(R)-8-[(2S,3S)-2-(tert-Butyl-diphenyl-silanyloxy)-3-methyl-pentanoyloxy]-8-((R)-2-methyl-oxiranyl)-octa-2,4,6-trienoic acid methyl ester
There total 46 articles about (2E,4E,6E)-(R)-8-[(2S,3S)-2-(tert-Butyl-diphenyl-silanyloxy)-3-methyl-pentanoyloxy]-8-((R)-2-methyl-oxiranyl)-octa-2,4,6-trienoic acid methyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1: sodium nitrite
2: p-toluenesulphonic acid
3: lithium carbonate, water / methanol
4: imidazole / dimethylformamide
5: H2 / palladium on carbon / ethanol
6: dicyclohexylcarbodiimide, 4-pyrrolidinopyridine / CH2Cl2
With
1H-imidazole; water; hydrogen; lithium carbonate; 4-pyrrolidin-1-ylpyridine; toluene-4-sulfonic acid; dicyclohexyl-carbodiimide; sodium nitrite;
palladium on activated charcoal;
In
methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1248/cpb.34.2668
- Guidance literature:
-
Multi-step reaction with 5 steps
1: p-toluenesulphonic acid
2: lithium carbonate, water / methanol
3: imidazole / dimethylformamide
4: H2 / palladium on carbon / ethanol
5: dicyclohexylcarbodiimide, 4-pyrrolidinopyridine / CH2Cl2
With
1H-imidazole; water; hydrogen; lithium carbonate; 4-pyrrolidin-1-ylpyridine; toluene-4-sulfonic acid; dicyclohexyl-carbodiimide;
palladium on activated charcoal;
In
methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1248/cpb.34.2668
- Guidance literature:
-
Multi-step reaction with 4 steps
1: lithium carbonate, water / methanol
2: imidazole / dimethylformamide
3: H2 / palladium on carbon / ethanol
4: dicyclohexylcarbodiimide, 4-pyrrolidinopyridine / CH2Cl2
With
1H-imidazole; water; hydrogen; lithium carbonate; 4-pyrrolidin-1-ylpyridine; dicyclohexyl-carbodiimide;
palladium on activated charcoal;
In
methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1248/cpb.34.2668