C₄₅H₅₅ClN₄O₈Si

Base Information

Chemical Name:C₄₅H₅₅ClN₄O₈Si
CAS No.:1312309-88-8
Molecular Formula:C₄₅H₅₅ClN₄O₈Si
Molecular Weight:843.492
Hs Code.:

C<sub>45</sub>H<sub>55</sub>ClN<sub>4</sub>O<sub>8</sub>Si

Synonyms:

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Chemical Property of C₄₅H₅₅ClN₄O₈Si

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Technology Process of C₄₅H₅₅ClN₄O₈Si

There total 10 articles about C₄₅H₅₅ClN₄O₈Si which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 9.0%

: 81731-43-3
2-isopropoxyethanamine

: 1254367-57-1
(4aS,11aR,12aS,13S)-8-bromo-10-chloro-13-(dimethylamino)-4a-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-11a,12,12a,13-tetrahydro-5-hydroxy-3,7-bis(phenylmethoxy)-isoxazolo[5',4':6,7]naphth[2,3-g]-isoquinoline-4,6(4aH,11H)-dione

: 1312309-88-8
C₄₅H₅₅ClN₄O₈Si

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; anhydrous dipotassium phosphate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; 1,4-dioxane; at 100 ℃; for 3h;
DOI:10.1021/jm1015389

Reference yield:

: 1254367-46-8
C₂₀H₁₆ClNO₄

: 1312309-88-8
C₄₅H₅₅ClN₄O₈Si

Guidance literature:: Multi-step reaction with 3 steps

1: phosphorus(V) oxybromide / toluene / 1 h / 80 °C

2: lithium hexamethyldisilazane / tetrahydrofuran / 1.17 h / -78 - 0 °C

3: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; anhydrous dipotassium phosphate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / tetrahydrofuran; 1,4-dioxane / 3 h / 100 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; anhydrous dipotassium phosphate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; lithium hexamethyldisilazane; phosphorus(V) oxybromide; In tetrahydrofuran; 1,4-dioxane; toluene;
DOI:10.1021/jm1015389

Reference yield:

: 1253799-61-9
3-(benzyloxy)-5-chloroisonicotinic acid

: 1312309-88-8
C₄₅H₅₅ClN₄O₈Si

Guidance literature:: Multi-step reaction with 9 steps

1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane

2: dmap; triethylamine / dichloromethane / 1 h

3: (bis(tricyclohexyl)phosphine)palladium(II) dichloride; anhydrous dipotassium phosphate / water; toluene / 16 h / 100 °C

4: dihydrogen peroxide / water; acetic acid / 6 h / 80 °C

5: trichlorophosphate / toluene / 2 h / 100 °C

6: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 20 °C

7: phosphorus(V) oxybromide / toluene / 1 h / 80 °C

8: lithium hexamethyldisilazane / tetrahydrofuran / 1.17 h / -78 - 0 °C

9: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; anhydrous dipotassium phosphate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / tetrahydrofuran; 1,4-dioxane / 3 h / 100 °C

With dmap; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; (bis(tricyclohexyl)phosphine)palladium(II) dichloride; anhydrous dipotassium phosphate; oxalyl dichloride; dihydrogen peroxide; triethylamine; N,N-dimethyl-formamide; 3-chloro-benzenecarboperoxoic acid; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; lithium hexamethyldisilazane; trichlorophosphate; phosphorus(V) oxybromide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; acetic acid; toluene; 3: Suzuki coupling;
DOI:10.1021/jm1015389