(2R,4S)-4-[(3,5-bis-trifluoromethyl-benzyl)-(2-methyl-2H-tetrazol-5-yl)-amino]-2-ethyl-trifluoromethyl-3,4-dihydro-2H-quinoline-1-carboxylic acid isopropyl ester

Base Information

Chemical Name:(2R,4S)-4-[(3,5-bis-trifluoromethyl-benzyl)-(2-methyl-2H-tetrazol-5-yl)-amino]-2-ethyl-trifluoromethyl-3,4-dihydro-2H-quinoline-1-carboxylic acid isopropyl ester
CAS No.:880103-60-6
Molecular Formula:C₂₇H₂₇F₉N₆O₂
Molecular Weight:638.536
Hs Code.:

(2R,4S)-4-[(3,5-bis-trifluoromethyl-benzyl)-(2-methyl-2H-tetrazol-5-yl)-amino]-2-ethyl-trifluoromethyl-3,4-dihydro-2H-quinoline-1-carboxylic acid isopropyl ester

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Chemical Property of (2R,4S)-4-[(3,5-bis-trifluoromethyl-benzyl)-(2-methyl-2H-tetrazol-5-yl)-amino]-2-ethyl-trifluoromethyl-3,4-dihydro-2H-quinoline-1-carboxylic acid isopropyl ester

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Technology Process of (2R,4S)-4-[(3,5-bis-trifluoromethyl-benzyl)-(2-methyl-2H-tetrazol-5-yl)-amino]-2-ethyl-trifluoromethyl-3,4-dihydro-2H-quinoline-1-carboxylic acid isopropyl ester

There total 10 articles about (2R,4S)-4-[(3,5-bis-trifluoromethyl-benzyl)-(2-methyl-2H-tetrazol-5-yl)-amino]-2-ethyl-trifluoromethyl-3,4-dihydro-2H-quinoline-1-carboxylic acid isopropyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 261947-57-3
[2R,4S]4-(3,5-bis-trifluoromethyl-benzylamino)-2-ethyl-6-trifluoromethyl-3,4-dihydro-2H-quinoline-1-carboxylic acid isopropyl ester

: 880103-60-6
(2R,4S)-4-[(3,5-bis-trifluoromethyl-benzyl)-(2-methyl-2H-tetrazol-5-yl)-amino]-2-ethyl-trifluoromethyl-3,4-dihydro-2H-quinoline-1-carboxylic acid isopropyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 20 °C

2: sodium azide; triethylamine / toluene / 110 °C

3: triphenylphosphine

With sodium azide; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In tetrahydrofuran; toluene; 3: Mitsunobu reaction;
DOI:10.1016/j.bmcl.2012.04.042

Reference yield:

: 667937-05-5
(3R)-3-(4-trifluoromethylphenylamino)pentanoic acid amide

: 880103-60-6
(2R,4S)-4-[(3,5-bis-trifluoromethyl-benzyl)-(2-methyl-2H-tetrazol-5-yl)-amino]-2-ethyl-trifluoromethyl-3,4-dihydro-2H-quinoline-1-carboxylic acid isopropyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: lithium tert-butoxide / tetrahydrofuran; diethyl ether / -10 - 0 °C

2: sodium tetrahydroborate; magnesium chloride / ethanol; water

3: pyridine / 0 - 20 °C

4: palladium 10% on activated carbon; hydrogen / ethyl acetate / 760.05 Torr

5: sodium tris(acetoxy)borohydride; acetic acid / 1,1-dichloroethane / 20 °C

6: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 20 °C

7: sodium azide; triethylamine / toluene / 110 °C

8: triphenylphosphine

With pyridine; sodium tetrahydroborate; sodium azide; sodium tris(acetoxy)borohydride; palladium 10% on activated carbon; hydrogen; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; magnesium chloride; lithium tert-butoxide; In tetrahydrofuran; diethyl ether; 1,1-dichloroethane; ethanol; water; ethyl acetate; toluene; 8: Mitsunobu reaction;
DOI:10.1016/j.bmcl.2012.04.042

Reference yield:

: 474645-99-3
C₂₄H₂₇F₃N₂O₄

: 880103-60-6
(2R,4S)-4-[(3,5-bis-trifluoromethyl-benzyl)-(2-methyl-2H-tetrazol-5-yl)-amino]-2-ethyl-trifluoromethyl-3,4-dihydro-2H-quinoline-1-carboxylic acid isopropyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: palladium 10% on activated carbon; hydrogen / ethyl acetate / 760.05 Torr

2: sodium tris(acetoxy)borohydride; acetic acid / 1,1-dichloroethane / 20 °C

3: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 20 °C

4: sodium azide; triethylamine / toluene / 110 °C

5: triphenylphosphine

With sodium azide; sodium tris(acetoxy)borohydride; palladium 10% on activated carbon; hydrogen; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In tetrahydrofuran; 1,1-dichloroethane; ethyl acetate; toluene; 5: Mitsunobu reaction;
DOI:10.1016/j.bmcl.2012.04.042