(2R)-2-({4-[([1,3]oxathiolo[5,4-c]pyridin-6-ylmethyl)amino]-1-piperidinyl}methyl)-1,2-dihydro-3H,8H-2a,5,8a-triazaacenaphthylene-3,8-dione benzoate

Base Information

• Chemical Name: (2R)-2-({4-[([1,3]oxathiolo[5,4-c]pyridin-6-ylmethyl)amino]-1-piperidinyl}methyl)-1,2-dihydro-3H,8H-2a,5,8a-triazaacenaphthylene-3,8-dione benzoate
• CAS No.: 1075234-98-8
• Molecular Formula: C₇H₆O₂*C₂₂H₂₄N₆O₃S
• Molecular Weight: 574.66
• Mol file: 1075234-98-8.mol

Synonyms:

Chemical Property of (2R)-2-({4-[([1,3]oxathiolo[5,4-c]pyridin-6-ylmethyl)amino]-1-piperidinyl}methyl)-1,2-dihydro-3H,8H-2a,5,8a-triazaacenaphthylene-3,8-dione benzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2R)-2-({4-[([1,3]oxathiolo[5,4-c]pyridin-6-ylmethyl)amino]-1-piperidinyl}methyl)-1,2-dihydro-3H,8H-2a,5,8a-triazaacenaphthylene-3,8-dione benzoate

There total 15 articles about (2R)-2-({4-[([1,3]oxathiolo[5,4-c]pyridin-6-ylmethyl)amino]-1-piperidinyl}methyl)-1,2-dihydro-3H,8H-2a,5,8a-triazaacenaphthylene-3,8-dione benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2R)-2-({4-[([1,3]oxathiolo[5,4-c]pyridin-6-ylmethyl)amino]-1-piperidinyl}methyl)-1,2-dihydro-3H,8H-2a,5,8a-triazaacenaphthylene-3,8-dione (1075234-97-7) + benzoic acid (65-85-0,8013-63-6) → (2R)-2-({4-[([1,3]oxathiolo[5,4-c]pyridin-6-ylmethyl)amino]-1-piperidinyl}methyl)-1,2-dihydro-3H,8H-2a,5,8a-triazaacenaphthylene-3,8-dione benzoate (1075234-98-8)

Guidance literature:

In methanol;

Reference yield:

2-{[6-(methyloxy)-3-nitro-2-pyridinyl]amino}-1,3-propanediol (757186-96-2) → (2R)-2-({4-[([1,3]oxathiolo[5,4-c]pyridin-6-ylmethyl)amino]-1-piperidinyl}methyl)-1,2-dihydro-3H,8H-2a,5,8a-triazaacenaphthylene-3,8-dione benzoate (1075234-98-8)

Guidance literature:

Multi-step reaction with 12 steps

1.1: toluene-4-sulfonic acid / 20 °C

1.2: 0.33 h

2.1: hydrogen / palladium 10% on activated carbon / 1,4-dioxane / 20 °C / 760.05 Torr

3.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C

4.1: sodium hydride / tetrahydrofuran / 3.25 h / 0 - 20 °C

5.1: manganese(IV) oxide / dichloromethane / 2 h / 20 °C

6.1: hydrogenchloride; water / tetrahydrofuran / 1 h / 20 °C

6.2: pH ~ 8

7.1: triethylamine / chloroform / 4.5 h / Heating / reflux

8.1: pyridine / acetonitrile / 5 h / 50 - 90 °C

9.1: hydrogenchloride / 1,4-dioxane; dichloromethane / 1 h / 20 °C

10.1: isopropylamine / methanol; acetonitrile / Resolution of racemate

11.1: methanol; chloroform / 2 h / 20 °C

11.2: 0.5 h / 20 °C

12.1: methanol

With pyridine; hydrogenchloride; manganese(IV) oxide; water; hydrogen; sodium hydride; potassium carbonate; toluene-4-sulfonic acid; isopropylamine; triethylamine; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; chloroform; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

2-chloro-6-methoxy-3-nitropyridine (38533-61-8) → (2R)-2-({4-[([1,3]oxathiolo[5,4-c]pyridin-6-ylmethyl)amino]-1-piperidinyl}methyl)-1,2-dihydro-3H,8H-2a,5,8a-triazaacenaphthylene-3,8-dione benzoate (1075234-98-8)

Guidance literature:

Multi-step reaction with 13 steps

1.1: ethanol; water / 4 h / 0 °C / Heating / reflux

2.1: toluene-4-sulfonic acid / 20 °C

2.2: 0.33 h

3.1: hydrogen / palladium 10% on activated carbon / 1,4-dioxane / 20 °C / 760.05 Torr

4.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C

5.1: sodium hydride / tetrahydrofuran / 3.25 h / 0 - 20 °C

6.1: manganese(IV) oxide / dichloromethane / 2 h / 20 °C

7.1: hydrogenchloride; water / tetrahydrofuran / 1 h / 20 °C

7.2: pH ~ 8

8.1: triethylamine / chloroform / 4.5 h / Heating / reflux

9.1: pyridine / acetonitrile / 5 h / 50 - 90 °C

10.1: hydrogenchloride / 1,4-dioxane; dichloromethane / 1 h / 20 °C

11.1: isopropylamine / methanol; acetonitrile / Resolution of racemate

12.1: methanol; chloroform / 2 h / 20 °C

12.2: 0.5 h / 20 °C

13.1: methanol

With pyridine; hydrogenchloride; manganese(IV) oxide; water; hydrogen; sodium hydride; potassium carbonate; toluene-4-sulfonic acid; isopropylamine; triethylamine; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; chloroform; water; N,N-dimethyl-formamide; acetonitrile;

upstream raw materials:

(2R)-2-({4-[([1,3]oxathiolo[5,4-c]pyridin-6-ylmethyl)amino]-1-piperidinyl}methyl)-1,2-dihydro-3H,8H-2a,5,8a-triazaacenaphthylene-3,8-dione

benzoic acid

2-{[6-(methyloxy)-3-nitro-2-pyridinyl]amino}-1,3-propanediol

2-chloro-6-methoxy-3-nitropyridine