(3′S,4S,9′S,11′S)-3,3″-bis({[2,6-bis(pyridin-2-yl)pyridin-4-yl]methyl})-1,1″-diphenyldispiro[imidazolidine-4,5′-[1,7]diazatricyclo[7.3.0.03,7]-dodecane-11′,4″-imidazolidine]-2,2′,2″,5,5″,8′-hexone

Base Information

Chemical Name:(3′S,4S,9′S,11′S)-3,3″-bis({[2,6-bis(pyridin-2-yl)pyridin-4-yl]methyl})-1,1″-diphenyldispiro[imidazolidine-4,5′-[1,7]diazatricyclo[7.3.0.03,7]-dodecane-11′,4″-imidazolidine]-2,2′,2″,5,5″,8′-hexone
CAS No.:1435402-68-8
Molecular Formula:C₅₈H₄₄N₁₂O₆
Molecular Weight:1005.06
Hs Code.:

(3′S,4S,9′S,11′S)-3,3″-bis({[2,6-bis(pyridin-2-yl)pyridin-4-yl]methyl})-1,1″-diphenyldispiro[imidazolidine-4,5′-[1,7]diazatricyclo[7.3.0.03,7]-dodecane-11′,4″-imidazolidine]-2,2′,2″,5,5″,8′-hexone

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Suppliers and Price of (3′S,4S,9′S,11′S)-3,3″-bis({[2,6-bis(pyridin-2-yl)pyridin-4-yl]methyl})-1,1″-diphenyldispiro[imidazolidine-4,5′-[1,7]diazatricyclo[7.3.0.03,7]-dodecane-11′,4″-imidazolidine]-2,2′,2″,5,5″,8′-hexone

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Chemical Property of (3′S,4S,9′S,11′S)-3,3″-bis({[2,6-bis(pyridin-2-yl)pyridin-4-yl]methyl})-1,1″-diphenyldispiro[imidazolidine-4,5′-[1,7]diazatricyclo[7.3.0.03,7]-dodecane-11′,4″-imidazolidine]-2,2′,2″,5,5″,8′-hexone

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Technology Process of (3′S,4S,9′S,11′S)-3,3″-bis({[2,6-bis(pyridin-2-yl)pyridin-4-yl]methyl})-1,1″-diphenyldispiro[imidazolidine-4,5′-[1,7]diazatricyclo[7.3.0.03,7]-dodecane-11′,4″-imidazolidine]-2,2′,2″,5,5″,8′-hexone

There total 4 articles about (3′S,4S,9′S,11′S)-3,3″-bis({[2,6-bis(pyridin-2-yl)pyridin-4-yl]methyl})-1,1″-diphenyldispiro[imidazolidine-4,5′-[1,7]diazatricyclo[7.3.0.03,7]-dodecane-11′,4″-imidazolidine]-2,2′,2″,5,5″,8′-hexone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 526222-99-1
(3S,5S)-1-((benzyloxy)carbonyl)-5-(tert-butoxycarbonyl)-3-aminopyrrolidine-3-carboxylic acid

: 1435402-68-8
(3′S,4S,9′S,11′S)-3,3″-bis({[2,6-bis(pyridin-2-yl)pyridin-4-yl]methyl})-1,1″-diphenyldispiro[imidazolidine-4,5′-[1,7]diazatricyclo[7.3.0.03,7]-dodecane-11′,4″-imidazolidine]-2,2′,2″,5,5″,8′-hexone

Guidance literature:: Multi-step reaction with 4 steps

1.1: methanol / 1 h / 20 °C

1.2: 20 °C

2.1: triethylamine / tetrahydrofuran / 20 °C

3.1: hydrogen bromide / acetic acid; dichloromethane / 3 h / 20 °C

4.1: HATU; N-ethyl-N,N-diisopropylamine / dichloromethane; N,N-dimethyl-formamide / 20 °C

With hydrogen bromide; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; In tetrahydrofuran; methanol; dichloromethane; acetic acid; N,N-dimethyl-formamide;
DOI:10.1021/ic4003498

Reference yield:

: 108295-45-0
4′-formyl-2,2′:6′2″-terpyridine

: 1435402-68-8
(3′S,4S,9′S,11′S)-3,3″-bis({[2,6-bis(pyridin-2-yl)pyridin-4-yl]methyl})-1,1″-diphenyldispiro[imidazolidine-4,5′-[1,7]diazatricyclo[7.3.0.03,7]-dodecane-11′,4″-imidazolidine]-2,2′,2″,5,5″,8′-hexone

Guidance literature:: Multi-step reaction with 4 steps

1.1: methanol / 1 h / 20 °C

1.2: 20 °C

2.1: triethylamine / tetrahydrofuran / 20 °C

3.1: hydrogen bromide / acetic acid; dichloromethane / 3 h / 20 °C

4.1: HATU; N-ethyl-N,N-diisopropylamine / dichloromethane; N,N-dimethyl-formamide / 20 °C

With hydrogen bromide; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; In tetrahydrofuran; methanol; dichloromethane; acetic acid; N,N-dimethyl-formamide;
DOI:10.1021/ic4003498

Reference yield:

: 1435402-63-3
7-benzyl 8-tert-butyl (5S,8S)-1-{[2,6-bis-(pyridin-2-yl)pyridin-4-yl]methyl}-2,4-dioxo-3-phenyl-1,3,7-triazaspiro[4.4]nonane-7,8-dicarboxylate

: 1435402-68-8
(3′S,4S,9′S,11′S)-3,3″-bis({[2,6-bis(pyridin-2-yl)pyridin-4-yl]methyl})-1,1″-diphenyldispiro[imidazolidine-4,5′-[1,7]diazatricyclo[7.3.0.03,7]-dodecane-11′,4″-imidazolidine]-2,2′,2″,5,5″,8′-hexone

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen bromide / acetic acid; dichloromethane / 3 h / 20 °C

2: HATU; N-ethyl-N,N-diisopropylamine / dichloromethane; N,N-dimethyl-formamide / 20 °C

With hydrogen bromide; N-ethyl-N,N-diisopropylamine; HATU; In dichloromethane; acetic acid; N,N-dimethyl-formamide;
DOI:10.1021/ic4003498