C₄₅H₄₆ClF₃N₄O₇S₄

Base Information

• Chemical Name: C₄₅H₄₆ClF₃N₄O₇S₄
• CAS No.: 1616557-72-2
• Molecular Formula: C₄₅H₄₆ClF₃N₄O₇S₄
• Molecular Weight: 975.595
• Mol file: 1616557-72-2.mol

Synonyms:

Chemical Property of C₄₅H₄₆ClF₃N₄O₇S₄

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₄₅H₄₆ClF₃N₄O₇S₄

There total 8 articles about C₄₅H₄₆ClF₃N₄O₇S₄ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C26H26ClNO3S (1627704-47-5) → C45H46ClF3N4O7S4 (1616557-72-2)

Guidance literature:

Multi-step reaction with 2 steps

1: lithium hydroxide; water / tetrahydrofuran; methanol / 100 °C

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane

With dmap; water; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane;

DOI:10.1016/j.bmcl.2014.05.036

Reference yield:

tert-butyl 4-bromo-1-piperidinecarboxylate (180695-79-8) → C45H46ClF3N4O7S4 (1616557-72-2)

Guidance literature:

Multi-step reaction with 7 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 85 °C

2.1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; 1,2-dimethoxyethane / 90 °C

3.1: hydrogenchloride

4.1: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 120 °C

5.1: sodium periodate / methanol; water / Reflux

5.2: Chiral AD column / Resolution of racemate

6.1: lithium hydroxide; water / tetrahydrofuran; methanol / 100 °C

7.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane

With hydrogenchloride; dmap; sodium periodate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; water; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; 2.1: |Suzuki Coupling;

DOI:10.1016/j.bmcl.2014.05.036

Reference yield:

C17H18ClNS (1616558-09-8) → C45H46ClF3N4O7S4 (1616557-72-2)

Guidance literature:

Multi-step reaction with 4 steps

1.1: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 120 °C

2.1: sodium periodate / methanol; water / Reflux

2.2: Chiral AD column / Resolution of racemate

3.1: lithium hydroxide; water / tetrahydrofuran; methanol / 100 °C

4.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane

With dmap; sodium periodate; water; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water; dimethyl sulfoxide;

DOI:10.1016/j.bmcl.2014.05.036

upstream raw materials:

C₂₆H₂₆ClNO₃S

[4-((R)-3-morpholin-4-yl-1-phenylsulfanyl-methyl-propylamino)-3-trifluoromethanesulfonyl]benzenesulfonamide

C₂₄H₂₂ClNO₃S

tert-butyl 4-bromo-1-piperidinecarboxylate