180695-79-8Relevant articles and documents
4-Hydroxy-1,2,3-triazole moiety as bioisostere of the carboxylic acid function: a novel scaffold to probe the orthosteric γ-aminobutyric acid receptor binding site
Giraudo, Alessandro,Krall, Jacob,Nielsen, Birgitte,S?rensen, Troels E.,Kongstad, Kenneth T.,Rolando, Barbara,Boschi, Donatella,Fr?lund, Bente,Lolli, Marco L.
, p. 311 - 321 (2018)
The correct application of bio(iso)steric replacement, a potent tool for the design of optimized compounds, requires the continuous development of new isosters able to respond to specific target requirements. Among carboxylic acid isosters, as the hydroxy
Reductive Radical Conjugate Addition of Alkyl Electrophiles Catalyzed by a Cobalt/Iridium Photoredox System
Escobar, Randolph A.,Johannes, Jeffrey W.
supporting information, p. 6046 - 6051 (2021/08/03)
Alkyl and aryl halides have been studied extensively as radical precursors; however, mild and less toxic conditions for the activation of alkyl bromides toward alkyl radicals are still desirable. Reported here is a reductive radical conjugate addition tha
Synthesis of Alkyl Halides from Aldehydes via Deformylative Halogenation
Liang, Shengzong,Kumon, Tatsuya,Angnes, Ricardo A.,Sanchez, Melissa,Xu, Bo,Hammond, Gerald B.
supporting information, p. 3848 - 3854 (2019/05/24)
An unprecedented deformylative halogenation of aldehydes to alkyl halides is presented. Under oxidative conditions, 1,4-dihydropyridine (DHP), derived from an aldehyde, generated a C(sp3)- radical that coupled with a halogen radical that was generated from inexpensive and atom-economical halogen sources (NaBr, NaI, or HCl), to yield an alkyl halide. Because of the mild conditions, a wide range of functional groups were tolerated, and excellent site selectivity was achieved.