CHMFL-BMX-078

Base Information

Chemical Name:CHMFL-BMX-078
CAS No.:1808288-51-8
Molecular Formula:C₃₃H₃₅N₇O₆
Molecular Weight:625.684
Hs Code.:
Mol file:1808288-51-8.mol

Synonyms:

Suppliers and Price of CHMFL-BMX-078

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

DC Chemicals
CHMFL-BMX-078 >98%
100 mg
$ 800.00

DC Chemicals
CHMFL-BMX-078 >98%
1 g
$ 3200.00

ChemScene
CHMFL-BMX-078 >98.0%
100mg
$ 2250.00

ChemScene
CHMFL-BMX-078 >98.0%
50mg
$ 1650.00

ChemScene
CHMFL-BMX-078 >98.0%
10mg
$ 550.00

ChemScene
CHMFL-BMX-078 >98.0%
5mg
$ 350.00

ChemScene
CHMFL-BMX-078 >98.0%
1mg
$ 120.00

Total 10 raw suppliers

Chemical Property of CHMFL-BMX-078

Chemical Property:

PKA:11.10±0.70(Predicted)
Density:1.335±0.06 g/cm3(Predicted)

Purity/Quality:

99%, ^*data from raw suppliers

CHMFL-BMX-078 >98% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of CHMFL-BMX-078

There total 10 articles about CHMFL-BMX-078 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 2-(3-amino-4-methylphenylamino)-N-(2-methyl-5-(3,4,5-trimethoxybenzamido)phenyl)-4-(methylamino)pyrimidine-5-carboxamide

: 814-68-6,25189-84-8
acryloyl chloride

: 1808288-51-8
2-(3-acrylamido-4-methylphenylamino)-N-(2-methyl-5-(3,4,5-trimethoxybenzamido)phenyl)-4-(methylamino)pyrimidine-5-carboxamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 0 - 20 ℃; for 3h; Inert atmosphere;
DOI:10.1021/acs.jmedchem.6b01413

Reference yield:

: N-(2-methyl-5-(3,4,5-trimethoxybenzamido)phenyl)-4-(methylamino)-2-(methylthio)pyrimidine-5-carboxamide

: 1808288-51-8
2-(3-acrylamido-4-methylphenylamino)-N-(2-methyl-5-(3,4,5-trimethoxybenzamido)phenyl)-4-(methylamino)pyrimidine-5-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 22 h / 0 - 20 °C / Inert atmosphere

2: trifluoroacetic acid / 1,4-dioxane / 2 h / 120 °C / Inert atmosphere

3: tin(II) chloride dihdyrate / methanol / 14 h / Inert atmosphere; Reflux

4: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 3 h / 0 - 20 °C / Inert atmosphere

With tin(II) chloride dihdyrate; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane;
DOI:10.1021/acs.jmedchem.6b01413

Reference yield:

: N-(2-methyl-5-(3,4,5-trimethoxybenzamido)phenyl)-4-(methylamino)-2-(methylsulfonyl)pyrimidine-5-carboxamide

: 1808288-51-8
2-(3-acrylamido-4-methylphenylamino)-N-(2-methyl-5-(3,4,5-trimethoxybenzamido)phenyl)-4-(methylamino)pyrimidine-5-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: trifluoroacetic acid / 1,4-dioxane / 2 h / 120 °C / Inert atmosphere

2: tin(II) chloride dihdyrate / methanol / 14 h / Inert atmosphere; Reflux

3: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 3 h / 0 - 20 °C / Inert atmosphere

With tin(II) chloride dihdyrate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; methanol;
DOI:10.1021/acs.jmedchem.6b01413