Methyl 4'-[[[2-(methoxycarbonyl)-6-nitrophenyl]amino]methyl][1,1'-biphenyl]-2-carboxylate

Base Information

Chemical Name:Methyl 4'-[[[2-(methoxycarbonyl)-6-nitrophenyl]amino]methyl][1,1'-biphenyl]-2-carboxylate
CAS No.:139481-36-0
Molecular Formula:C23H20N2O6
Molecular Weight:420.422
Hs Code.:
DSSTox Substance ID:DTXSID301123006

Synonyms:SCHEMBL3974372;DTXSID301123006;139481-36-0

Suppliers and Price of Methyl 4'-[[[2-(methoxycarbonyl)-6-nitrophenyl]amino]methyl][1,1'-biphenyl]-2-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of Methyl 4'-[[[2-(methoxycarbonyl)-6-nitrophenyl]amino]methyl][1,1'-biphenyl]-2-carboxylate

Chemical Property:

XLogP3:5.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:8
Exact Mass:420.13213636
Heavy Atom Count:31
Complexity:628

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:COC(=O)C1=C(C(=CC=C1)[N+](=O)[O-])NCC2=CC=C(C=C2)C3=CC=CC=C3C(=O)OC

Technology Process of Methyl 4'-[[[2-(methoxycarbonyl)-6-nitrophenyl]amino]methyl][1,1'-biphenyl]-2-carboxylate

There total 6 articles about Methyl 4'-[[[2-(methoxycarbonyl)-6-nitrophenyl]amino]methyl][1,1'-biphenyl]-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 150058-11-0
4'-{[tert-Butoxycarbonyl-(2-methoxycarbonyl-6-nitro-phenyl)-amino]-methyl}-biphenyl-2-carboxylic acid methyl ester

: 139481-36-0
methyl 2-<<<2'-(methoxycarbonyl)biphenyl-4-yl>methyl>amino>-3-nitrobenzoate

Guidance literature:: With hydrogenchloride; In ethyl acetate; for 1h; Yield given; Ambient temperature;
DOI:10.1021/jm00067a016

Reference yield:

: 21606-04-2
methyl 2-carboxy-3-nitrobenzoate

: 139481-36-0
methyl 2-<<<2'-(methoxycarbonyl)biphenyl-4-yl>methyl>amino>-3-nitrobenzoate

Guidance literature:: Multi-step reaction with 5 steps

1: SOCl₂, DMF / toluene / 0.5 h / Heating

2: NaN₃ / acetone; H₂O / 1 h

3: 1.5 h / Heating

4: K₂CO₃ / acetonitrile / 4 h / Heating

5: 30percent ethanolic HCl / ethyl acetate / 1 h / Ambient temperature

With hydrogenchloride; thionyl chloride; sodium azide; potassium carbonate; N,N-dimethyl-formamide; In water; ethyl acetate; acetone; toluene; acetonitrile;
DOI:10.1021/jm00067a016

Reference yield:

: 73833-13-3
acid chloride of 1-methylhydrogen-3-nitrophthalate

: 139481-36-0
methyl 2-<<<2'-(methoxycarbonyl)biphenyl-4-yl>methyl>amino>-3-nitrobenzoate

Guidance literature:: Multi-step reaction with 4 steps

1: NaN₃ / acetone; H₂O / 1 h

2: 1.5 h / Heating

3: K₂CO₃ / acetonitrile / 4 h / Heating

4: 30percent ethanolic HCl / ethyl acetate / 1 h / Ambient temperature

With hydrogenchloride; sodium azide; potassium carbonate; In water; ethyl acetate; acetone; acetonitrile;
DOI:10.1021/jm00067a016