Technology Process of {1-{(methoxymethyl)oxy}-3-phenylpropyl}tributylstannane
There total 3 articles about {1-{(methoxymethyl)oxy}-3-phenylpropyl}tributylstannane which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
N-ethyl-N,N-diisopropylamine;
In
dichloromethane;
under Ar; react. in CH2Cl2 for 4-6 h; partitioned between H2O and CH2Cl2, aq. layer was extd. with CH2Cl2, combined organic ext.were washed with brine, dried, volatiles were removed in vac., chromy. on silica gel;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: n-butyllithium; diisopropylamine / tetrahydrofuran; hexane / 0.25 h / 0 °C / Inert atmosphere
1.2: 0.08 h / -78 °C / Inert atmosphere
2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 7 h / -10 - 20 °C / Inert atmosphere
With
n-butyllithium; diisopropylamine; N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran; hexane; dichloromethane;
DOI:10.1021/acs.joc.5b02043
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: n-butyllithium; diisopropylamine / tetrahydrofuran; hexane / 0.25 h / 0 °C / Inert atmosphere
1.2: 0.08 h / -78 °C / Inert atmosphere
2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 7 h / -10 - 20 °C / Inert atmosphere
With
n-butyllithium; diisopropylamine; N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran; hexane; dichloromethane;
DOI:10.1021/acs.joc.5b02043
