Technology Process of 4-hydroxy-4-phenyl-but-2-enoic acid
There total 6 articles about 4-hydroxy-4-phenyl-but-2-enoic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
3-benzoylacrylic acid;
With
methanol; sodium tetrahydroborate;
at 20 ℃;
for 4h;
Acidic conditions;
DOI:10.3762/bjoc.6.94
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere
2.1: L-Selectride / tetrahydrofuran; diethyl ether / 1 h / -78 °C / Inert atmosphere
2.2: 1 h / -78 - 20 °C / Inert atmosphere
3.1: hydrogenchloride; water / chloroform / 6 h / Reflux
With
hydrogenchloride; water; L-Selectride; triethylamine;
In
tetrahydrofuran; diethyl ether; dichloromethane; chloroform;
DOI:10.1016/j.tetlet.2011.08.143
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: potassium hydroxide / methanol / 25 - 40 °C
2.1: hydrogenchloride / water
3.1: Dichloromethyl methyl ether / 1 h / 50 °C / Inert atmosphere
4.1: triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere
5.1: L-Selectride / tetrahydrofuran; diethyl ether / 1 h / -78 °C / Inert atmosphere
5.2: 1 h / -78 - 20 °C / Inert atmosphere
6.1: hydrogenchloride; water / chloroform / 6 h / Reflux
With
hydrogenchloride; Dichloromethyl methyl ether; water; L-Selectride; triethylamine; potassium hydroxide;
In
tetrahydrofuran; methanol; diethyl ether; dichloromethane; chloroform; water;
DOI:10.1016/j.tetlet.2011.08.143
