alpaha-cyano-beta-hydroxy-N-(4-(trifluoromethyl)phenyl)-3-(4-(trifluoromethyl)phenyl)propenamide

Base Information

Chemical Name:alpaha-cyano-beta-hydroxy-N-(4-(trifluoromethyl)phenyl)-3-(4-(trifluoromethyl)phenyl)propenamide
CAS No.:136185-95-0
Molecular Formula:C18H10 F6 N2 O2
Molecular Weight:400.27
Hs Code.:
Mol file:136185-95-0.mol

Synonyms:alpaha-cyano-beta-hydroxy-N-(4-(trifluoromethyl)phenyl)-3-(4-(trifluoromethyl)phenyl)propenamide

Suppliers and Price of alpaha-cyano-beta-hydroxy-N-(4-(trifluoromethyl)phenyl)-3-(4-(trifluoromethyl)phenyl)propenamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of alpaha-cyano-beta-hydroxy-N-(4-(trifluoromethyl)phenyl)-3-(4-(trifluoromethyl)phenyl)propenamide

Chemical Property:

Vapor Pressure:4.33E-08mmHg at 25°C
Boiling Point:428.1°Cat760mmHg
Flash Point:212.7°C
PSA：73.12000
Density:1.488g/cm³
LogP:5.22858

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of alpaha-cyano-beta-hydroxy-N-(4-(trifluoromethyl)phenyl)-3-(4-(trifluoromethyl)phenyl)propenamide

There total 5 articles about alpaha-cyano-beta-hydroxy-N-(4-(trifluoromethyl)phenyl)-3-(4-(trifluoromethyl)phenyl)propenamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 5-(4-Trifluoromethyl-phenyl)-isoxazole-4-carboxylic acid (4-trifluoromethyl-phenyl)-amide

: 136185-95-0
α-cyano-β-hydroxy-N-<4'-(trifluoromethyl)phenyl>-3-<4-(trifluoromethyl)phenyl>propenamide

Guidance literature:: With ethanol; sodium ethanolate; for 0.25h;
DOI:10.1021/jm9604437

Reference yield:

: 455-14-1
4-trifluoromethylphenylamine

: 136185-95-0
α-cyano-β-hydroxy-N-<4'-(trifluoromethyl)phenyl>-3-<4-(trifluoromethyl)phenyl>propenamide

Guidance literature:: Multi-step reaction with 2 steps

1: CH₂Cl₂ / 0.5 h / Ambient temperature

2: 97 percent / NaOEt, EtOH / 0.25 h

With ethanol; sodium ethanolate; In dichloromethane;
DOI:10.1021/jm9604437

Reference yield:

: 5-[4-(Trifluoromethyl)phenyl]isoxazole-4-carboxylic acid

: 136185-95-0
α-cyano-β-hydroxy-N-<4'-(trifluoromethyl)phenyl>-3-<4-(trifluoromethyl)phenyl>propenamide

Guidance literature:: Multi-step reaction with 3 steps

1: SOCl₂ / 1 h / 50 °C

2: CH₂Cl₂ / 0.5 h / Ambient temperature

3: 97 percent / NaOEt, EtOH / 0.25 h

With thionyl chloride; ethanol; sodium ethanolate; In dichloromethane;
DOI:10.1021/jm9604437