4-(2-((5-fluoro-6-methoxypyridin-3-yl)amino)-5-(1-(4-(methylsulfonyl)piperazin-1-yl)ethyl)pyridin-3-yl)-N,N-bis(4-methoxybenzyl)-6-methyl-1,3,5-triazin-2-amine

Base Information

Chemical Name:4-(2-((5-fluoro-6-methoxypyridin-3-yl)amino)-5-(1-(4-(methylsulfonyl)piperazin-1-yl)ethyl)pyridin-3-yl)-N,N-bis(4-methoxybenzyl)-6-methyl-1,3,5-triazin-2-amine
CAS No.:1253571-16-2
Molecular Formula:C₃₈H₄₄FN₉O₅S
Molecular Weight:757.889
Hs Code.:

4-(2-((5-fluoro-6-methoxypyridin-3-yl)amino)-5-(1-(4-(methylsulfonyl)piperazin-1-yl)ethyl)pyridin-3-yl)-N,N-bis(4-methoxybenzyl)-6-methyl-1,3,5-triazin-2-amine

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Chemical Property of 4-(2-((5-fluoro-6-methoxypyridin-3-yl)amino)-5-(1-(4-(methylsulfonyl)piperazin-1-yl)ethyl)pyridin-3-yl)-N,N-bis(4-methoxybenzyl)-6-methyl-1,3,5-triazin-2-amine

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Technology Process of 4-(2-((5-fluoro-6-methoxypyridin-3-yl)amino)-5-(1-(4-(methylsulfonyl)piperazin-1-yl)ethyl)pyridin-3-yl)-N,N-bis(4-methoxybenzyl)-6-methyl-1,3,5-triazin-2-amine

There total 7 articles about 4-(2-((5-fluoro-6-methoxypyridin-3-yl)amino)-5-(1-(4-(methylsulfonyl)piperazin-1-yl)ethyl)pyridin-3-yl)-N,N-bis(4-methoxybenzyl)-6-methyl-1,3,5-triazin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 55276-43-2
4-methanesulfonylpiperazine

: 1253575-95-9
1-(5-(4-(bis(4-methoxybenzyl)amino)-6-methyl-1,3,5-triazin-2-yl)-6-((5-fluoro-6-methoxypyridin-3-yl)amino)pyridin-3-yl)ethyl methanesulfonate

: 1253571-16-2
4-(2-((5-fluoro-6-methoxypyridin-3-yl)amino)-5-(1-(4-(methylsulfonyl)piperazin-1-yl)ethyl)pyridin-3-yl)-N,N-bis(4-methoxybenzyl)-6-methyl-1,3,5-triazin-2-amine

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; Inert atmosphere;
DOI:10.1021/jm300846z

Reference yield:

: 886372-63-0
5-fluoro-6-methoxypyridin-3-ylamine

: 1253571-16-2
4-(2-((5-fluoro-6-methoxypyridin-3-yl)amino)-5-(1-(4-(methylsulfonyl)piperazin-1-yl)ethyl)pyridin-3-yl)-N,N-bis(4-methoxybenzyl)-6-methyl-1,3,5-triazin-2-amine

Guidance literature:: Multi-step reaction with 5 steps

1: lithium hexamethyldisilazane / tetrahydrofuran / 0.58 h / Cooling with ice; Inert atmosphere

2: hydrogenchloride; water / tetrahydrofuran; methanol / 0.17 h / 20 °C / Inert atmosphere

3: tetrahydrofuran; diethyl ether / 0.42 h / 0 °C

4: triethylamine / dichloromethane / 2 h

5: triethylamine / dichloromethane / 20 °C / Inert atmosphere

With hydrogenchloride; water; triethylamine; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; diethyl ether; dichloromethane;
DOI:10.1021/jm300846z

Reference yield:

: 1253571-14-0
5-(4-(bis(4-methoxybenzyl)-amino)-6-methyl-1,3,5-triazin-2-yl)-6-((5-fluoro-6-methoxypyridin-3-yl)amino)nicotinaldehyde

: 1253571-16-2
4-(2-((5-fluoro-6-methoxypyridin-3-yl)amino)-5-(1-(4-(methylsulfonyl)piperazin-1-yl)ethyl)pyridin-3-yl)-N,N-bis(4-methoxybenzyl)-6-methyl-1,3,5-triazin-2-amine

Guidance literature:: Multi-step reaction with 3 steps

1: tetrahydrofuran; diethyl ether / 0.42 h / 0 °C

2: triethylamine / dichloromethane / 2 h

3: triethylamine / dichloromethane / 20 °C / Inert atmosphere

With triethylamine; In tetrahydrofuran; diethyl ether; dichloromethane;
DOI:10.1021/jm300846z