1-O-<11-(Methoxycarbonyl)undecyl>-2-O-methyl-sn-3-glyceryl o-chlorophenyl ethyl phosphate

Base Information

• Chemical Name: 1-O-<11-(Methoxycarbonyl)undecyl>-2-O-methyl-sn-3-glyceryl o-chlorophenyl ethyl phosphate
• CAS No.: 153959-48-9
• Molecular Formula: C₃₀H₅₁ClNO₁₀P
• Molecular Weight: 652.162
• Mol file: 153959-48-9.mol

Synonyms:

Chemical Property of 1-O-<11-(Methoxycarbonyl)undecyl>-2-O-methyl-sn-3-glyceryl o-chlorophenyl ethyl phosphate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-O-<11-(Methoxycarbonyl)undecyl>-2-O-methyl-sn-3-glyceryl o-chlorophenyl ethyl phosphate

There total 7 articles about 1-O-<11-(Methoxycarbonyl)undecyl>-2-O-methyl-sn-3-glyceryl o-chlorophenyl ethyl phosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

12-hydroxydodecanoic acid (505-95-3) → 1-O-<11-(Methoxycarbonyl)undecyl>-2-O-methyl-sn-3-glyceryl o-chlorophenyl ethyl phosphate (153959-48-9)

Guidance literature:

Multi-step reaction with 5 steps

1: 99 percent / 1 M HCl / 12 h / Ambient temperature

2: 71.7 percent / BF₃*Et₂O / CHCl₃ / Ambient temperature

3: NaH / hexane; tetrahydrofuran

4: TBAF / tetrahydrofuran

5: pyridine / tetrahydrofuran / 36 h

With pyridine; hydrogenchloride; boron trifluoride diethyl etherate; tetrabutyl ammonium fluoride; sodium hydride; In tetrahydrofuran; hexane; chloroform;

DOI:10.1021/jo00082a009

Reference yield:

methyl 12-hydroxydodecanoate (71655-36-2) → 1-O-<11-(Methoxycarbonyl)undecyl>-2-O-methyl-sn-3-glyceryl o-chlorophenyl ethyl phosphate (153959-48-9)

Guidance literature:

Multi-step reaction with 4 steps

1: 71.7 percent / BF₃*Et₂O / CHCl₃ / Ambient temperature

2: NaH / hexane; tetrahydrofuran

3: TBAF / tetrahydrofuran

4: pyridine / tetrahydrofuran / 36 h

With pyridine; boron trifluoride diethyl etherate; tetrabutyl ammonium fluoride; sodium hydride; In tetrahydrofuran; hexane; chloroform;

DOI:10.1021/jo00082a009

Reference yield:

2-(N-tert-butoxycarbonylamino)ethanol (26690-80-2) → 1-O-<11-(Methoxycarbonyl)undecyl>-2-O-methyl-sn-3-glyceryl o-chlorophenyl ethyl phosphate (153959-48-9)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / tetrahydrofuran / 6 h

2: pyridine / tetrahydrofuran / 36 h

With pyridine; In tetrahydrofuran;

DOI:10.1021/jo00082a009

upstream raw materials:

1-O-<11-(Methoxycarbonyl)undecyl>-2-O-methyl-sn-glycerol

{2-[Chloro-(2-chloro-phenoxy)-phosphoryloxy]-ethyl}-carbamic acid tert-butyl ester

12-hydroxydodecanoic acid

methyl 12-hydroxydodecanoate