(R)-3-(4-chlorophenyl)-4-(3-(4-(4-(4-((4-(dimethylamino)-1-(phenylthio)butan-2-yl)amino)-3-nitrophenylsulfonamido)phenyl)piperazin-1-yl)phenyl)-1-methyl-1H-pyrazole-5-carboxylic acid

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Chemical Name:(R)-3-(4-chlorophenyl)-4-(3-(4-(4-(4-((4-(dimethylamino)-1-(phenylthio)butan-2-yl)amino)-3-nitrophenylsulfonamido)phenyl)piperazin-1-yl)phenyl)-1-methyl-1H-pyrazole-5-carboxylic acid
CAS No.:1391107-59-7
Molecular Formula:C₄₅H₄₇ClN₈O₆S₂
Molecular Weight:895.503
Hs Code.:

(R)-3-(4-chlorophenyl)-4-(3-(4-(4-(4-((4-(dimethylamino)-1-(phenylthio)butan-2-yl)amino)-3-nitrophenylsulfonamido)phenyl)piperazin-1-yl)phenyl)-1-methyl-1H-pyrazole-5-carboxylic acid

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Chemical Property of (R)-3-(4-chlorophenyl)-4-(3-(4-(4-(4-((4-(dimethylamino)-1-(phenylthio)butan-2-yl)amino)-3-nitrophenylsulfonamido)phenyl)piperazin-1-yl)phenyl)-1-methyl-1H-pyrazole-5-carboxylic acid

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Technology Process of (R)-3-(4-chlorophenyl)-4-(3-(4-(4-(4-((4-(dimethylamino)-1-(phenylthio)butan-2-yl)amino)-3-nitrophenylsulfonamido)phenyl)piperazin-1-yl)phenyl)-1-methyl-1H-pyrazole-5-carboxylic acid

There total 10 articles about (R)-3-(4-chlorophenyl)-4-(3-(4-(4-(4-((4-(dimethylamino)-1-(phenylthio)butan-2-yl)amino)-3-nitrophenylsulfonamido)phenyl)piperazin-1-yl)phenyl)-1-methyl-1H-pyrazole-5-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1391108-14-7
methyl 3-(4-chlorophenyl)-1-methyl-1H-pyrazole-5-carboxylate

: 1391107-59-7
(R)-3-(4-chlorophenyl)-4-(3-(4-(4-(4-((4-(dimethylamino)-1-(phenylthio)butan-2-yl)amino)-3-nitrophenylsulfonamido)phenyl)piperazin-1-yl)phenyl)-1-methyl-1H-pyrazole-5-carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1: ammonium cerium (IV) nitrate; N-iodo-succinimide / acetonitrile / 70 °C

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; water; potassium carbonate / 1,2-dimethoxyethane / 2 h / 90 °C / Inert atmosphere

3: palladium 10% on activated carbon; hydrogen / methanol / 0.25 h / 760.05 Torr / Inert atmosphere

4: pyridine / 0.5 h / 0 °C

5: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide

With pyridine; N-iodo-succinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; ammonium cerium (IV) nitrate; palladium 10% on activated carbon; water; hydrogen; potassium carbonate; N-ethyl-N,N-diisopropylamine; In methanol; 1,2-dimethoxyethane; N,N-dimethyl-formamide; acetonitrile; 2: |Suzuki Coupling;
DOI:10.1021/jm4001105

Reference yield:

: 39757-35-2
methyl 4-(4-chlorophenyl)-2,4-dioxobutanoate

: 1391107-59-7
(R)-3-(4-chlorophenyl)-4-(3-(4-(4-(4-((4-(dimethylamino)-1-(phenylthio)butan-2-yl)amino)-3-nitrophenylsulfonamido)phenyl)piperazin-1-yl)phenyl)-1-methyl-1H-pyrazole-5-carboxylic acid

Guidance literature:: Multi-step reaction with 6 steps

1: acetic acid / ethanol / 3 h / 20 °C

2: ammonium cerium (IV) nitrate; N-iodo-succinimide / acetonitrile / 70 °C

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾; water; potassium carbonate / 1,2-dimethoxyethane / 2 h / 90 °C / Inert atmosphere

4: palladium 10% on activated carbon; hydrogen / methanol / 0.25 h / 760.05 Torr / Inert atmosphere

5: pyridine / 0.5 h / 0 °C

6: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide

With pyridine; N-iodo-succinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; ammonium cerium (IV) nitrate; palladium 10% on activated carbon; water; hydrogen; potassium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; In methanol; 1,2-dimethoxyethane; ethanol; N,N-dimethyl-formamide; acetonitrile; 3: |Suzuki Coupling;
DOI:10.1021/jm4001105

Reference yield:

: 1391108-15-8
methyl 3-(4-chlorophenyl)-4-iodo-1-methyl-1H-pyrazole-5-carboxylate

: 1391107-59-7
(R)-3-(4-chlorophenyl)-4-(3-(4-(4-(4-((4-(dimethylamino)-1-(phenylthio)butan-2-yl)amino)-3-nitrophenylsulfonamido)phenyl)piperazin-1-yl)phenyl)-1-methyl-1H-pyrazole-5-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; water; potassium carbonate / 1,2-dimethoxyethane / 2 h / 90 °C / Inert atmosphere

2: palladium 10% on activated carbon; hydrogen / methanol / 0.25 h / 760.05 Torr / Inert atmosphere

3: pyridine / 0.5 h / 0 °C

4: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide

With pyridine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; water; hydrogen; potassium carbonate; N-ethyl-N,N-diisopropylamine; In methanol; 1,2-dimethoxyethane; N,N-dimethyl-formamide; 1: |Suzuki Coupling;
DOI:10.1021/jm4001105