methyl 3-(4-chlorophenyl)-1-methyl-1H-pyrazole-5-carboxylate

Base Information

• Chemical Name: methyl 3-(4-chlorophenyl)-1-methyl-1H-pyrazole-5-carboxylate
• CAS No.: 1391108-14-7
• Molecular Formula: C₁₂H₁₁ClN₂O₂
• Molecular Weight: 250.685
• Mol file: 1391108-14-7.mol

Synonyms:methyl 3-(4-chlorophenyl)-1-methyl-1H-pyrazole-5-carboxylate

Chemical Property of methyl 3-(4-chlorophenyl)-1-methyl-1H-pyrazole-5-carboxylate

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Methyl3-(4-chlorophenyl)-1-methyl-1H-pyrazole-5-carboxylate 97% ^*data from reagent suppliers

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Technology Process of methyl 3-(4-chlorophenyl)-1-methyl-1H-pyrazole-5-carboxylate

There total 4 articles about methyl 3-(4-chlorophenyl)-1-methyl-1H-pyrazole-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

methylhydrazine (60-34-4) + methyl 4-(4-chlorophenyl)-2,4-dioxobutanoate (39757-35-2) → methyl 3-(4-chlorophenyl)-1-methyl-1H-pyrazole-5-carboxylate (1391108-14-7) + methyl 5-(4-chlorophenyl)-1-methyl-1H-pyrazole-3-carboxylate (1275687-89-2)

Guidance literature:

With acetic acid; In ethanol; at 20 ℃; for 3h;

DOI:10.1021/jm4001105

Reference yield:

methyl 3‐(4‐chlorophenyl)‐1H‐pyrazole‐5‐carboxylate (79508-09-1) + methyl iodide (74-88-4) → methyl 3-(4-chlorophenyl)-1-methyl-1H-pyrazole-5-carboxylate (1391108-14-7)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 50 ℃;

DOI:10.1016/j.ejmech.2013.03.048

Reference yield:

para-chloroacetophenone (99-91-2) → methyl 3-(4-chlorophenyl)-1-methyl-1H-pyrazole-5-carboxylate (1391108-14-7)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium methylate / methanol / 20 °C

2: acetic acid; hydrazine hydrate / Reflux

3: potassium carbonate / N,N-dimethyl-formamide / 50 °C

With sodium methylate; potassium carbonate; hydrazine hydrate; acetic acid; In methanol; N,N-dimethyl-formamide; 1: |Claisen Condensation;

DOI:10.1016/j.ejmech.2013.03.048

upstream raw materials:

methylhydrazine

methyl 4-(4-chlorophenyl)-2,4-dioxobutanoate

para-chloroacetophenone

methyl 3‐(4‐chlorophenyl)‐1H‐pyrazole‐5‐carboxylate

Downstream raw materials:

methyl 3-(4-chlorophenyl)-4-iodo-1-methyl-1H-pyrazole-5-carboxylate

3-(4-chlorophenyl)-1-methyl-4-(3-(4-(4-nitrophenyl)-piperazin-1-yl)phenyl)-1H-pyrazole-5-carboxylic acid

(R)-3-(4-chlorophenyl)-4-(3-(4-(4-(4-((4-(dimethylamino)-1-(phenylthio)butan-2-yl)amino)-3-nitrophenylsulfonamido)phenyl)piperazin-1-yl)phenyl)-1-methyl-1H-pyrazole-5-carboxylic acid

(3-(4-chlorophenyl)-1-methyl-1H-pyrazol-5-yl)(piperidin-1-yl)methanone

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