C₁₈H₂₈N₂O₂

Base Information

• Chemical Name: C₁₈H₂₈N₂O₂
• CAS No.: 1121599-93-6
• Molecular Formula: C₁₈H₂₈N₂O₂
• Molecular Weight: 304.433
• Mol file: 1121599-93-6.mol

Synonyms:

Chemical Property of C₁₈H₂₈N₂O₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₈H₂₈N₂O₂

There total 1 articles about C₁₈H₂₈N₂O₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-iso-propylbromobenzene (586-61-8) + 1-t-Butoxycarbonylpiperazine (57260-71-6) → C18H28N2O2 (1121599-93-6)

Guidance literature:

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium tert-butylate; tris-(o-tolyl)phosphine; In toluene; at 100 ℃; for 18h;

DOI:10.1016/j.bmcl.2012.09.003

Reference yield:

C18H28N2O2 (1121599-93-6) → 4-[4-(1-methylethyl)phenyl]piperazine (68104-59-6)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2h;

DOI:10.1016/j.bmcl.2012.09.003

Reference yield:

C18H28N2O2 (1121599-93-6) → C22H29N3O2

Guidance literature:

Multi-step reaction with 2 steps

1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 3 h / 20 °C

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2012.09.003

upstream raw materials:

4-iso-propylbromobenzene

1-t-Butoxycarbonylpiperazine

Downstream raw materials:

4-[4-(1-methylethyl)phenyl]piperazine

Refernces