tert-butylammonium (2R)-3-cyclohexyl-2-[[2-[[2-[4-[(2R,3R)-1-(4-fluorophenyl)-3-[(2R)-2-(4-fluorophenyl)-2-hydroxyethyl]thio-4-oxoazetidin-2-yl]phenoxy]acetyl]-amino]acetyl]amino]propanoate

Base Information

Chemical Name:tert-butylammonium (2R)-3-cyclohexyl-2-[[2-[[2-[4-[(2R,3R)-1-(4-fluorophenyl)-3-[(2R)-2-(4-fluorophenyl)-2-hydroxyethyl]thio-4-oxoazetidin-2-yl]phenoxy]acetyl]-amino]acetyl]amino]propanoate
CAS No.:1369489-35-9
Molecular Formula:C₄H₁₁N*C₃₆H₃₉F₂N₃O₇S
Molecular Weight:768.922
Hs Code.:

tert-butylammonium (2R)-3-cyclohexyl-2-[[2-[[2-[4-[(2R,3R)-1-(4-fluorophenyl)-3-[(2R)-2-(4-fluorophenyl)-2-hydroxyethyl]thio-4-oxoazetidin-2-yl]phenoxy]acetyl]-amino]acetyl]amino]propanoate

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Chemical Property of tert-butylammonium (2R)-3-cyclohexyl-2-[[2-[[2-[4-[(2R,3R)-1-(4-fluorophenyl)-3-[(2R)-2-(4-fluorophenyl)-2-hydroxyethyl]thio-4-oxoazetidin-2-yl]phenoxy]acetyl]-amino]acetyl]amino]propanoate

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Technology Process of tert-butylammonium (2R)-3-cyclohexyl-2-[[2-[[2-[4-[(2R,3R)-1-(4-fluorophenyl)-3-[(2R)-2-(4-fluorophenyl)-2-hydroxyethyl]thio-4-oxoazetidin-2-yl]phenoxy]acetyl]-amino]acetyl]amino]propanoate

There total 19 articles about tert-butylammonium (2R)-3-cyclohexyl-2-[[2-[[2-[4-[(2R,3R)-1-(4-fluorophenyl)-3-[(2R)-2-(4-fluorophenyl)-2-hydroxyethyl]thio-4-oxoazetidin-2-yl]phenoxy]acetyl]-amino]acetyl]amino]propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1369489-34-8
C₃₆H₃₉F₂N₃O₇S

: 1369489-35-9
tert-butylammonium (2R)-3-cyclohexyl-2-[[2-[[2-[4-[(2R,3R)-1-(4-fluorophenyl)-3-[(2R)-2-(4-fluorophenyl)-2-hydroxyethyl]thio-4-oxoazetidin-2-yl]phenoxy]acetyl]-amino]acetyl]amino]propanoate

Guidance literature:: With tert-butylamine; In acetone; at 35 ℃; for 70h; Inert atmosphere;
DOI:10.1021/op200314z

Reference yield:

: 73620-18-5
methyl (4-formylphenoxy)acetate

: 1369489-35-9
tert-butylammonium (2R)-3-cyclohexyl-2-[[2-[[2-[4-[(2R,3R)-1-(4-fluorophenyl)-3-[(2R)-2-(4-fluorophenyl)-2-hydroxyethyl]thio-4-oxoazetidin-2-yl]phenoxy]acetyl]-amino]acetyl]amino]propanoate

Guidance literature:: Multi-step reaction with 10 steps

1.1: toluene / Reflux; Inert atmosphere

2.1: titanium(IV) isopropylate; titanium tetrachloride / dichloromethane / 0.17 h / Inert atmosphere

2.2: 0.33 h / -30 °C / Inert atmosphere

3.1: N,O-bis-(trimethylsilyl)-acetamide / toluene / 1 h / 90 °C / Inert atmosphere

3.2: 21 h / 45 °C / Inert atmosphere

4.1: formic acid / dichloromethane / 16 h / 20 °C / Inert atmosphere

5.1: triethylamine; lithium chloride / water; acetonitrile / 18 h / 20 °C / Inert atmosphere

6.1: 4-methyl-morpholine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / dichloromethane / 1 h / 20 °C / Inert atmosphere

7.1: formic acid / 6 h / 35 °C / Inert atmosphere

8.1: sodium tetrahydroborate / methanol / Inert atmosphere

9.1: 4-methyl-morpholine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 1 h / 20 °C / Inert atmosphere

9.2: 1 h / 20 °C / Inert atmosphere

10.1: tert-butylamine / acetone / 70 h / 35 °C / Inert atmosphere

With 4-methyl-morpholine; titanium(IV) isopropylate; sodium tetrahydroborate; formic acid; N,O-bis-(trimethylsilyl)-acetamide; titanium tetrachloride; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; tert-butylamine; triethylamine; lithium chloride; In methanol; dichloromethane; water; N,N-dimethyl-formamide; acetone; toluene; acetonitrile;
DOI:10.1021/op200314z

Reference yield:

: 1369489-36-0
methyl 2-[4-[(E)-(4-fluorophenyl)iminomethyl]phenoxy]acetate

: 1369489-35-9
tert-butylammonium (2R)-3-cyclohexyl-2-[[2-[[2-[4-[(2R,3R)-1-(4-fluorophenyl)-3-[(2R)-2-(4-fluorophenyl)-2-hydroxyethyl]thio-4-oxoazetidin-2-yl]phenoxy]acetyl]-amino]acetyl]amino]propanoate

Guidance literature:: Multi-step reaction with 6 steps

1: 2-chloro-1-methyl-pyridinium iodide; triethylamine / dichloromethane / 16 h / 23 °C / Inert atmosphere

2: water; triethylamine; lithium chloride / acetonitrile / 24 h / 13 - 20 °C / Inert atmosphere

3: acetic acid; lithium chloride / water / 10 - 25 °C / Inert atmosphere

4: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine / N,N-dimethyl-formamide / 18.75 h / -15 - 0 °C / Inert atmosphere

5: lithium chloride / N,N-dimethyl-formamide / 96 h / 30 °C / Inert atmosphere

6: tert-butylamine / acetone / 70 h / 35 °C / Inert atmosphere

With 2-chloro-1-methyl-pyridinium iodide; water; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; acetic acid; tert-butylamine; triethylamine; lithium chloride; In dichloromethane; water; N,N-dimethyl-formamide; acetone; acetonitrile; 1: Staudinger reaction;
DOI:10.1021/op200314z