73620-18-5Relevant academic research and scientific papers
Synthesis and antileukemic activity of 16E-[4-(2-carboxy)ethoxybenzylidene] -androstene amides
Bansal, Ranju,Acharya, Pratap Chandra
, p. 552 - 557 (2012)
In order to determine the structural requirements for cytotoxicity against various tumor cell lines, a new series of 16E-arylidene androstene amides with varying degrees of unsaturation in ring A has been synthesized. Characterization and in vitro cytotox
Phosphatase Binding Compounds and Methods of Using Same
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Page/Page column 232; 251-252, (2020/07/25)
The present invention provides bifunctional compounds that efficiently dephosphorylate certain phospho-activated target proteins. Such target proteins can be any protein involved in the pathway of a disease or disorder, such as but not limited to cancer, neurodegeneration, metabolic disease, diabetes, insulin resistance, and so forth.
INHIBITORS OF SHORT-CHAIN DEHYDROGENASE ACTIVITY FOR PROMOTING NEUROGENESIS AND INHIBITING NERVE CELL DEATH
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Paragraph 00285, (2018/02/27)
A method of promoting neuroprotection in a subject from axonal degeneration, neuronal cell death, and/or glia cell damage after injury, augmenting neuronal signaling underlying learning and memory, stimulating neuronal regeneration after injury, and/or treating a disease, disorder, and/or condition of the nervous system in a subject in need thereof includes administering to the subject a therapeutically effective amount of a 15-PGDH inhibitor.
Boosting Self-Assembly Diversity in the Solid-State by Chiral/Non-Chiral ZnII-Porphyrin Crystallization
Qian, Wenjie,González-Campo, Arántzazu,Pérez-Rodríguez, Ana,Rodríguez-Hermida, Sabina,Imaz, Inhaz,Wurst, Klaus,Maspoch, Daniel,Ruiz, Eliseo,Ocal, Carmen,Barrena, Esther,Amabilino, David B.,Aliaga-Alcalde, Núria
supporting information, p. 12950 - 12960 (2018/08/11)
A chiral ZnII porphyrin derivative 1 and its achiral analogue 2 were studied in the solid state. Considering the rich molecular recognition of designed metalloporphyrins 1 and 2 and their tendency to crystallize, they were recrystallized from t
INHIBITORS OF SHORT-CHAIN DEHYDROGENASE ACTIVITY FOR TREATING FIBROSIS
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Paragraph 00296, (2016/09/26)
A method of treating or preventing a fibrotic disease, disorder or condition includes administering to a subject in need of treatment a 15-PGDH inhibitor.
A process for the preparation of intermediates palestinian multi-past fragrance acetate
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Paragraph 0100-0103, (2017/01/31)
The invention discloses a method for preparing a bazedoxifene acetate intermediate. The preparation method comprises the following steps: 1, condensing 4-hydroxybenzaldehyde S01 and alkylate S02 to prepare a 4-formyl phenoxy derivative M01; 2, performing
Synthesis and pharmacological characterization of novel xanthine carboxylate amides as A2A adenosine receptor ligands exhibiting bronchospasmolytic activity
Yadav, Rakesh,Bansal, Ranju,Rohilla, Suman,Kachler, Sonja,Klotz, Karl-Norbert
, p. 26 - 37 (2016/02/18)
The carboxylate amides of 8-phenyl-1,3-dimethylxanthine described herein represent a new series of selective ligands of the adenosine A2A receptors exhibiting bronchospasmolytic activity. The effects of location of 8-phenyl substitutions on the
COMPOSITIONS AND METHODS OF MODULATING SHORT-CHAIN DEHYDROGENASE ACTIVITY
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Paragraph 00490, (2015/05/19)
Compounds and methods of modulating 15-PGDH activity, modulating tissue prostaglandin levels, treating disease, diseases disorders, or conditions in which it is desired to modulate 15-PGDH activity and/or prostaglandin levels include 15-PGDH inhibitors described herein.
Selection and development of a route for cholesterol absorption inhibitor AZD4121
Karlsson, Staffan,Soerensen, J. Henrik
experimental part, p. 586 - 594 (2012/07/03)
The development of a synthetic route to the cholesterol absorption inhibitor AZD4121 is presented. Key steps are a highly enantioselective CBS reduction, a stereospecific Staudinger reaction, an amine/lithium chloride mediated ester hydrolysis, and a resolution of a 50:50 diastereomeric mixture by recrystallization. The synthesis was accomplished in 10 linear steps, and the overall yield, when compared with the lead optimization (LO) route, was improved from 1% to 20%. All purifications of intermediates through preparative HPLC or silica gel chromatography were avoided. This was possible since many of the intermediates along the route could be used as such in the next step until an intermediate with suitable crystalline properties could be identified and purified through crystallization.
Novel Compounds
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Page/Page column 33, (2011/06/24)
The present invention provides compounds of formula (I): wherein Ra, Rb, Rc, R1, R2, R3, X1, Y1, Z1, A, n and m are as defined in the specification, and pharmaceutically acceptable salts thereof, as well as processes for their preparation, pharmaceutical compositions containing them and their use in therapy.
