L-Alanine, N-[(S)-hydroxyphenoxyphosphinyl]-, 1-Methylethyl ester, (P→3'),(P'→5')-diester with (2'R)-2'-deoxy-2'-fluoro-2'-Methyluridine

Base Information

Chemical Name:L-Alanine, N-[(S)-hydroxyphenoxyphosphinyl]-, 1-Methylethyl ester, (P→3'),(P'→5')-diester with (2'R)-2'-deoxy-2'-fluoro-2'-Methyluridine
CAS No.:1337482-17-3
Molecular Formula:C₃₄H₄₅FN₄O₁₃P₂
Molecular Weight:798.696
Hs Code.:
Mol file:1337482-17-3.mol

Synonyms:

Suppliers and Price of L-Alanine, N-[(S)-hydroxyphenoxyphosphinyl]-, 1-Methylethyl ester, (P→3'),(P'→5')-diester with (2'R)-2'-deoxy-2'-fluoro-2'-Methyluridine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Sofosbuvir3'',5''-Bis-(S)-phosphate
250mg
$ 1320.00

Medical Isotopes, Inc.
Sofosbuvir3??,5??-Bis-(S)-phosphate
25 mg
$ 650.00

Medical Isotopes, Inc.
Sofosbuvir3??,5??-Bis-(S)-phosphate
250 mg
$ 2200.00

ChemScene
SofosbuvirimpurityF
5mg
$ 4200.00

ChemScene
SofosbuvirimpurityF
1mg
$ 1800.00

Total 11 raw suppliers

Chemical Property of L-Alanine, N-[(S)-hydroxyphenoxyphosphinyl]-, 1-Methylethyl ester, (P→3'),(P'→5')-diester with (2'R)-2'-deoxy-2'-fluoro-2'-Methyluridine

Chemical Property:

PKA:9.39±0.10(Predicted)
Density:1.37±0.1 g/cm3(Predicted)

Purity/Quality:

97% ^*data from raw suppliers

Sofosbuvir3'',5''-Bis-(S)-phosphate ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses Sofosbuvir Impurity Sofosbuvir 3'',5''-Bis-(S)-phosphate is an impurity of PSI-7977 (P839640), a prodrug that is metabolized to the active antiviral agent 2''-deoxy-2''-α-fluoro-β-C-methyluridine-5''-monophosphate and is currently being investigated in phase 3 clinical trials for the treatment of hepatitis C. Studies have profiled PSI-7977 as a nucleotide inhibitor of hepatitis C virus, exerting selective inhibitory effects towards HCV NS5B polymerase.

Technology Process of L-Alanine, N-[(S)-hydroxyphenoxyphosphinyl]-, 1-Methylethyl ester, (P→3'),(P'→5')-diester with (2'R)-2'-deoxy-2'-fluoro-2'-Methyluridine

There total 4 articles about L-Alanine, N-[(S)-hydroxyphenoxyphosphinyl]-, 1-Methylethyl ester, (P→3'),(P'→5')-diester with (2'R)-2'-deoxy-2'-fluoro-2'-Methyluridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 261909-49-3
phenyl(isopropoxy-L-alaninyl) phosphorochloridate

: 863329-66-2,2041584-99-8
2'-deoxy-2'-fluoro-2'-methyluridine

: 1064684-44-1,1496552-16-9
sofosbuvir

: 1337482-17-3
C₃₄H₄₅FN₄O₁₃P₂

Guidance literature:: With tert-butylmagnesium chloride; In tetrahydrofuran; at 20 ℃; for 17.5h; Inert atmosphere; Molecular sieve;

Reference yield:

: 261909-49-3
phenyl(isopropoxy-L-alaninyl) phosphorochloridate

: 863329-66-2,2041584-99-8
2'-deoxy-2'-fluoro-2'-methyluridine

: 1190307-88-0,1496552-16-9
sofosbuvir

: 1190308-01-0,1496552-16-9
(S)-2-{(R)-[(2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-ylmethoxy](phenoxy)phosphorylamino}propionic acid isopropyl ester

: 1337482-17-3
C₃₄H₄₅FN₄O₁₃P₂

Guidance literature:: With 1-methyl-1H-imidazole; In tetrahydrofuran; at 0 - 20 ℃; for 2.75h; Reagent/catalyst; Time; Solvent; Optical yield = 18 %de; Inert atmosphere;

Reference yield:

: 863329-66-2,2041584-99-8
2'-deoxy-2'-fluoro-2'-methyluridine

: 1334513-02-8,1627824-09-2
(S)-2-[(S)-((2,3,4,5,6-pentafluorophenoxy)(phenoxy)phosphoryl)amino]propionic acid isopropyl ester

: 1190307-88-0,1496552-16-9
sofosbuvir

: 1337482-17-3
(S)-isopropyl 2-(((S)-(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-2-((((S)-(((S)-1-isopropoxy-1-oxopropan-2-yl)amino)(phenoxy)phosphoryl)oxy)methyl)-4-methyltetrahydrofuran-3-yl)oxy)(phenoxy)phosphoryl)amino)propanoate

Guidance literature:: With pyridine; dimethylaluminum chloride; In hexane; at 0 - 20 ℃; for 20h; Reagent/catalyst; diastereoselective reaction; Inert atmosphere;
DOI:10.1021/acs.orglett.7b00469