261909-49-3

Basic information

• Product Name: L-Alanine, N-(chlorophenoxyphosphinyl)-, 1-Methylethyl ester
• Synonyms: L-Alanine, N-(chlorophenoxyphosphinyl)-, 1-Methylethyl ester;N-(Chlorophenoxyphosphinyl)-L-alanine 1-methylethyl ester;isopropyl(chloro(phenoxy)phosphoryl)-L-alaninate;phenyl(isopropoxy-L-alaninyl) phosphorochloridate;EOS-60850
• CAS NO: 261909-49-3
• Molecular Formula: C₁₂H₁₇ClNO₄P
• Molecular Weight: 305.694441
• EINECS: -0
• Mol File: 261909-49-3.mol
• Article Data: 68

Chemical Properties

• Boiling Point: 376.5±44.0 °C(Predicted)
• Appearance: white powder
• Density: 1.249±0.06 g/cm3 (20 oC 760 Torr)
• PKA: -6.04±0.70(Predicted)
• CAS DataBase Reference: L-Alanine, N-(chlorophenoxyphosphinyl)-, 1-Methylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: L-Alanine, N-(chlorophenoxyphosphinyl)-, 1-Methylethyl ester(261909-49-3)
• EPA Substance Registry System: L-Alanine, N-(chlorophenoxyphosphinyl)-, 1-Methylethyl ester(261909-49-3)

Safety Data

• Hazardous Substances Data: 261909-49-3(Hazardous Substances Data)

Usage

General Description

L-Alanine, N-(chlorophenoxyphosphinyl)-, 1-methylethyl ester is a chemical compound that is a derivative of L-alanine, which is a non-essential amino acid. The compound also contains a chlorophenoxyphosphinyl group and an isopropyl ester group. This chemical may be used in organic synthesis and as a reagent in chemical reactions. It may also have potential applications in the development of pharmaceuticals or other bioactive compounds. It is important to handle and use this compound with caution, following proper safety protocols and handling procedures.

Synthetic route

O-phenyl phosphorodichloridate (770-12-7) + alanine isopropyl ester hydrochloride (39613-92-8, 62062-56-0, 62062-65-1) → phenyl(isopropoxy-L-alaninyl) phosphorochloridate (261909-49-3)

Conditions	Yield
With triethylamine In tert-butyl methyl ether at -65 - -50℃; for 2h; Inert atmosphere; Cooling with acetone-dry ice;	100%
With triethylamine In tert-butyl methyl ether at -55℃; for 2h;	100%
With triethylamine In dichloromethane at -78 - 20℃; for 2.5h; Inert atmosphere;	93%

isopropyl L-alanine (39825-33-7) + O-phenyl phosphorodichloridate (770-12-7) → phenyl(isopropoxy-L-alaninyl) phosphorochloridate (261909-49-3)

Conditions	Yield
With triethylamine In dichloromethane at -78 - 20℃; for 1.25h; Inert atmosphere;	99%
With triethylamine In dichloromethane	78%
With N-ethyl-N,N-diisopropylamine In dichloromethane at -80℃; for 2h;

O-phenyl phosphorodichloridate (770-12-7) + (isopropoxy-2-oxo-ethyl-L-alaninyl)ammonium salt → phenyl(isopropoxy-L-alaninyl) phosphorochloridate (261909-49-3)

Conditions	Yield
With triethylamine In dichloromethane at -78 - 20℃; Inert atmosphere;	80%

toluene-4-sulfonic acid; compound with 2-amino-propionic acid isopropyl ester + O-phenyl phosphorodichloridate (770-12-7) → phenyl(isopropoxy-L-alaninyl) phosphorochloridate (261909-49-3)

Conditions	Yield
With triethylamine In dichloromethane at -78 - 20℃;	55%
With triethylamine In dichloromethane at -78 - 20℃;

toluene-4-sulfonic acid (104-15-4) → phenyl(isopropoxy-L-alaninyl) phosphorochloridate (261909-49-3)

Conditions	Yield
Multi-step reaction with 2 steps 1: toluene / Heating 2: triethylamine / CH2Cl2 / -78 - 20 °C View Scheme
Multi-step reaction with 2 steps 1: toluene / 24 h / 120 °C 2: triethylamine / dichloromethane / -78 - 20 °C View Scheme

phenol (108-95-2) → phenyl(isopropoxy-L-alaninyl) phosphorochloridate (261909-49-3)

Conditions	Yield
Multi-step reaction with 2 steps 1: trichlorophosphate; triethylamine / dichloromethane / 2 h / -78 - 20 °C 2: triethylamine / dichloromethane / 2 h / -78 - 20 °C View Scheme
Multi-step reaction with 2 steps 1: trichlorophosphate; triethylamine / dichloromethane / -78 - 20 °C 2: triethylamine / dichloromethane / 2 h / -78 °C View Scheme
Multi-step reaction with 2 steps 1: triethylamine; trichlorophosphate / dichloromethane / 2 h / -78 - 20 °C 2: triethylamine / dichloromethane / 2 h / -78 - 20 °C View Scheme

C6H12ClNO2 + O-phenyl phosphorodichloridate (770-12-7) → phenyl(isopropoxy-L-alaninyl) phosphorochloridate (261909-49-3)

Conditions	Yield
With triethylamine In dichloromethane at -78 - 20℃;	760 g

phenyl(isopropoxy-L-alaninyl) phosphorochloridate (261909-49-3) + 2,3,4,5,6-pentafluorophenol (771-61-9) → (S)-2-[(2,3,4,5,6-pentafluorophenoxy)phenoxyphosphorylamino]propionic acid isopropyl ester (1256490-52-4)

Conditions	Yield
With triethylamine In dichloromethane at 0 - 25℃; for 1h; Inert atmosphere;	100%
With triethylamine In dichloromethane at -5 - 20℃; for 20.33h; Inert atmosphere;	41%
With triethylamine In dichloromethane at 0 - 20℃; Inert atmosphere;

phenyl(isopropoxy-L-alaninyl) phosphorochloridate (261909-49-3) + 1-[(2R,3R,4R,5R)-4-(benzyloxy)-3-fluoro-5-(hydroxymethyl)-3-methyltetrahydrofuran-2-yl]pyrimidine-2,4(1H,3H)-dione → (2S)-isopropyl 2-{[({(2R,3R,4R,5R)-3-(benzyloxy)-5-[2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl]-4-fluoro-4-methyltetrahydrofuran-2-yl}methoxy)(phenoxy)phosphoryl]amino}propanoate

Conditions	Yield
Stage #1: 1-[(2R,3R,4R,5R)-4-(benzyloxy)-3-fluoro-5-(hydroxymethyl)-3-methyltetrahydrofuran-2-yl]pyrimidine-2,4(1H,3H)-dione With isopropylmagnesium chloride, lithium chloride complex In tetrahydrofuran at -20℃; for 2h; Stage #2: phenyl(isopropoxy-L-alaninyl) phosphorochloridate In tetrahydrofuran at -20℃; for 4h;	99%

phenyl(isopropoxy-L-alaninyl) phosphorochloridate (261909-49-3) + C22H41FN2O6Si2 → C34H57FN3O10PSi2

Conditions	Yield
Stage #1: C22H41FN2O6Si2 With isopropylmagnesium chloride In tetrahydrofuran at -25℃; for 2h; Stage #2: phenyl(isopropoxy-L-alaninyl) phosphorochloridate In tetrahydrofuran at -25 - -5℃; for 15h; Temperature;	99%

phenyl(isopropoxy-L-alaninyl) phosphorochloridate (261909-49-3) + 1-((3aR,4R,6S,6aS)-6-fluoro-6-(hydroxymethyl)-2-methoxy-3a-methyltetrahydrofuro [3,4-d][1,3]dioxol-4-yl)pyrimidine-2,4-(1H,3H)-dione (1613589-05-1) → C24H31FN3O11P

Conditions	Yield
Stage #1: 1-((3aR,4R,6S,6aS)-6-fluoro-6-(hydroxymethyl)-2-methoxy-3a-methyltetrahydrofuro [3,4-d][1,3]dioxol-4-yl)pyrimidine-2,4-(1H,3H)-dione With isopropylmagnesium chloride In tetrahydrofuran at 0℃; for 0.333333h; Stage #2: phenyl(isopropoxy-L-alaninyl) phosphorochloridate In tetrahydrofuran at 20℃;	93%
Stage #1: 1-((3aR,4R,6S,6aS)-6-fluoro-6-(hydroxymethyl)-2-methoxy-3a-methyltetrahydrofuro [3,4-d][1,3]dioxol-4-yl)pyrimidine-2,4-(1H,3H)-dione With isopropylmagnesium chloride In tetrahydrofuran at 0℃; for 0.333333h; Stage #2: phenyl(isopropoxy-L-alaninyl) phosphorochloridate In tetrahydrofuran at 0 - 20℃;	93%
Stage #1: 1-((3aR,4R,6S,6aS)-6-fluoro-6-(hydroxymethyl)-2-methoxy-3a-methyltetrahydrofuro [3,4-d][1,3]dioxol-4-yl)pyrimidine-2,4-(1H,3H)-dione With isopropylmagnesium chloride In tetrahydrofuran at 0℃; for 0.333333h; Stage #2: phenyl(isopropoxy-L-alaninyl) phosphorochloridate In tetrahydrofuran at 20℃;	93%
Stage #1: 1-((3aR,4R,6S,6aS)-6-fluoro-6-(hydroxymethyl)-2-methoxy-3a-methyltetrahydrofuro [3,4-d][1,3]dioxol-4-yl)pyrimidine-2,4-(1H,3H)-dione With isopropylmagnesium chloride In tetrahydrofuran at 0℃; for 0.333333h; Stage #2: phenyl(isopropoxy-L-alaninyl) phosphorochloridate In tetrahydrofuran at 20℃;	93%

phenyl(isopropoxy-L-alaninyl) phosphorochloridate (261909-49-3) + O2',O3'-isopropylidene-1-methyl-guanosine (23392-07-6) → C26H35N6O9P

Conditions	Yield
With 1-methyl-1H-imidazole In tetrahydrofuran; acetonitrile at 20℃; for 3h;	91%

phenyl(isopropoxy-L-alaninyl) phosphorochloridate (261909-49-3) + (2R,3R,4R,5R)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-4-chloro-4-fluoro-2-(hydroxymethyl)tetrahydrofuran-3-yl tert-butyl carbonate → isopropyl ((((2R,3R,4R,5R)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-3-((tert-butoxycarbonyl)oxy)-4-chloro-4-fluorotetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)-L-alaninate

Conditions	Yield
With tert-butylmagnesium chloride In tetrahydrofuran at 20℃; for 1h;	89%
Stage #1: (2R,3R,4R,5R)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-4-chloro-4-fluoro-2-(hydroxymethyl)tetrahydrofuran-3-yl tert-butyl carbonate With tert-butylmagnesium chloride In tetrahydrofuran at 0℃; for 0.333333h; Stage #2: phenyl(isopropoxy-L-alaninyl) phosphorochloridate In tetrahydrofuran at 20℃; for 1h;	89%

phenyl(isopropoxy-L-alaninyl) phosphorochloridate (261909-49-3) + 5(R)-<5-methyl-2,4(1H,3H)-pyrimidinedione>tetrahydro-3(S)-furanmethanol (146558-01-2) → 1'-(thymin-1-yl)-2',3'-dideoxy-β-D-apio-D-furanose [phenyl-(isopropoxy-L-alaninyl)]phosphate (1610460-03-1)

Conditions	Yield
With 1-methyl-1H-imidazole In tetrahydrofuran at 25℃; for 48h; Inert atmosphere;	88%

phenyl(isopropoxy-L-alaninyl) phosphorochloridate (261909-49-3) + 2',3'-O-cyclopentylidene-4'-azidoinosine (926309-62-8) → C27H33N8O9P (1170666-22-4)

Conditions	Yield
With tert-butylmagnesium bromide In tetrahydrofuran at 20℃; for 17h;	87%

phenyl(isopropoxy-L-alaninyl) phosphorochloridate (261909-49-3) + 1-((1R,3S,5S)-3-(hydroxymethyl)-2-oxabicyclo[3.1.0]hexan-1-yl)pyrimidine-2,4(1H,3H)-dione → isopropyl((((1R,3S,5S)-1-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2-oxabicyclo[3.1.0]hexan-3-yl)methoxy)(phenoxy)phosphoryl)-L-alaninate

Conditions	Yield
Stage #1: 1-((1R,3S,5S)-3-(hydroxymethyl)-2-oxabicyclo[3.1.0]hexan-1-yl)pyrimidine-2,4(1H,3H)-dione With tert-butylmagnesium chloride In tetrahydrofuran at 20℃; for 0.5h; Inert atmosphere; Stage #2: phenyl(isopropoxy-L-alaninyl) phosphorochloridate In tetrahydrofuran for 2h; Inert atmosphere;	85%

phenyl(isopropoxy-L-alaninyl) phosphorochloridate (261909-49-3) + (2R,3R,5R)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-4,4-difluoro-2-(hydroxymethyl)tetrahydrofuran-3-yl tert-butyl carbonate (250698-51-2) → 2′-deoxy-2′,2′-difluoro-3′-O-(tert-butoxycarbonyloxy)-D-cytidine-5′-O-[phenyl(isopropoxy-L-alaninyl)]phosphate

Conditions	Yield
With tert-butylmagnesium chloride In tetrahydrofuran at 20℃; for 16h; Inert atmosphere;	84%

phenyl(isopropoxy-L-alaninyl) phosphorochloridate (261909-49-3) + diethyl (2-amino-9-((2R,3R,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)-3-methyltetrahydrofuran-2-yl)-9H-purin-6-yl)phosphonate (1345969-94-9) → isopropyl ((((2R,3R,4R,5R)-5-(2-amino-6-(diethoxyphosphoryl)-9H-purin-9-yl)-3,4-dihydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)-L-alaninate

Conditions	Yield
With 1-methyl-1H-imidazole In tetrahydrofuran; acetonitrile at 20℃; for 3h;	77%

phenyl(isopropoxy-L-alaninyl) phosphorochloridate (261909-49-3) + 4-amino-1-((1R,3S,5S)-3-(hydroxymethyl)-2-oxabicyclo[3.1.0]hexan-1-yl)pyrimidin-2(1H)-one → C22H29N4O7P

Conditions	Yield
Stage #1: 4-amino-1-((1R,3S,5S)-3-(hydroxymethyl)-2-oxabicyclo[3.1.0]hexan-1-yl)pyrimidin-2(1H)-one With tert-butylmagnesium chloride In tetrahydrofuran at 20℃; for 0.5h; Inert atmosphere; Stage #2: phenyl(isopropoxy-L-alaninyl) phosphorochloridate In tetrahydrofuran Inert atmosphere;	72%

phenyl(isopropoxy-L-alaninyl) phosphorochloridate (261909-49-3) + (3S,4R,5S,6R)-3-acetamido-6-(hydroxymethyl)-tetrahydro-2H-pyran-2,4,5-triyl triacetate (63597-75-1) → (3S,4R,5S,6R)-3-acetamido-6-((((((S)-1-isopropoxy-1-oxopropan-2-yl)amino)(phenoxy)phosphoryl)oxy)methyl)tetrahydro-2H-pyran-2,4,5-triyl triacetate

Conditions	Yield
Stage #1: (3S,4R,5S,6R)-3-acetamido-6-(hydroxymethyl)-tetrahydro-2H-pyran-2,4,5-triyl triacetate With tert-butylmagnesium chloride In tetrahydrofuran at 0℃; for 0.5h; Inert atmosphere; Stage #2: phenyl(isopropoxy-L-alaninyl) phosphorochloridate In tetrahydrofuran at 0 - 20℃; for 12h; Inert atmosphere;	68%

phenyl(isopropoxy-L-alaninyl) phosphorochloridate (261909-49-3) + C21H34N2O5Si → isopropyl ((((3aS,4R,6R,6aR)-4-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2,2-dimethyl-tetrahydrospiro[cyclopenta[d][1,3] dioxole-5,1’-cyclopropan]-6-yl)methoxy)(phenoxy)phos phoryl)-L-alaninate

Conditions	Yield
With 1-methyl-1H-imidazole In tetrahydrofuran at -78 - 20℃; Inert atmosphere;	68%

phenyl(isopropoxy-L-alaninyl) phosphorochloridate (261909-49-3) + sodium pentafluorophenolate (2263-53-8) → (S)-2-[((S)-(2,3,4,5,6-pentafluorophenoxy)(phenoxy)phosphoryl)amino]propionic acid isopropyl ester (1334513-02-8)

Conditions	Yield
Stage #1: phenyl(isopropoxy-L-alaninyl) phosphorochloridate; sodium pentafluorophenolate In tetrahydrofuran at -10℃; Stage #2: With triethylamine In n-heptane; tert-butyl methyl ether pH=8;	66.81%

phenyl(isopropoxy-L-alaninyl) phosphorochloridate (261909-49-3) + 4-((benzyloxy)amino)-1-((2R,3R,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)-3-methyltetrahydrofuran-2-yl)pyrimidin-2(1H)-one (1609192-93-9) → (2S)-isopropyl 2-(((((2R,3R,4R,5R)-5-(4-((benzyloxy)amino)-2-oxopyrimidin-1(2H)-yl)-3,4-dihydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)amino)propanoate (1609193-17-0)

Conditions	Yield
With 1-methyl-1H-imidazole In tetrahydrofuran at 20℃; for 3h; Inert atmosphere;	66%

phenyl(isopropoxy-L-alaninyl) phosphorochloridate (261909-49-3) + 2',3'-O,O-cyclopentylidene-4'-azidouridine (926309-54-8) → 2-propyl N-[{1-[(3aR,4R,6R,6aS)-4-azido-tetrahydro-4-(hydroxymethyl)-2,2-cyclopentylfuro[3,4-d][1,3]dioxol-6-yl]pyrimidine-2,4(1H,3H)-dione} (phenoxy)-phosphoryl]-L-alaninate

Conditions	Yield
Stage #1: 2',3'-O,O-cyclopentylidene-4'-azidouridine With tert-butylmagnesium chloride In tetrahydrofuran for 0.25h; Stage #2: phenyl(isopropoxy-L-alaninyl) phosphorochloridate In tetrahydrofuran for 17h; Further stages.;	64%

phenyl(isopropoxy-L-alaninyl) phosphorochloridate (261909-49-3) + (+)-9-[(1′R,2′R,3′R,4′R)-2′-fluoro-3′-hydroxy-4′-(hydroxymethyl)-5′-methylenecyclopentan-1′-yl]-adenine (1307273-70-6) → {[(1R,3R,4R)-3-(6-amino-9H-purin-9-yl)-4-fluoro-5-hydroxy-2-methylenecyclopentyl]methoxy}(phenoxyphosphoryl amino) propionic Acid Isopropyl Ester

Conditions	Yield
With 1-methyl-1H-imidazole In tetrahydrofuran at 0 - 20℃; Inert atmosphere;	61%

phenyl(isopropoxy-L-alaninyl) phosphorochloridate (261909-49-3) + 5'-(5-hexadecyl-2-oxido-1,3,2-dioxaphosphinan-2-yl)phospho-AZT → 5'-(phosphoamidate-phospho)-AZT

Conditions	Yield
With triethylamine In 1,4-dioxane; acetonitrile for 18h;	60%

phenyl(isopropoxy-L-alaninyl) phosphorochloridate (261909-49-3) + 5-(6-amino-9H-purin-9-yl)-2,2,3,3,4,4-hexafluoropentan-1-ol → isopropyl (((5-(6-amino-9H-purin-9-yl)-2,2,3,3,4,4-hexafluoropentyl)oxy)(phenoxy)phosphoryl)-L-alaninate

Conditions	Yield
Stage #1: 5-(6-amino-9H-purin-9-yl)-2,2,3,3,4,4-hexafluoropentan-1-ol With 1-methyl-1H-imidazole In tetrahydrofuran at 0℃; for 0.25h; Stage #2: phenyl(isopropoxy-L-alaninyl) phosphorochloridate In tetrahydrofuran at 20℃; for 2h;	60%

phenyl(isopropoxy-L-alaninyl) phosphorochloridate (261909-49-3) + N'-(9-((2-hydroxyethoxy)-methyl)-6-oxo-6,9-dihydro-1H-purin-2-yl)-N,N-dimethylformimidamide (100699-59-0) → C23H32N7O7P (1184942-68-4)

Conditions	Yield
With tert-butylmagnesium chloride In tetrahydrofuran at 20℃; Inert atmosphere;	59%

phenyl(isopropoxy-L-alaninyl) phosphorochloridate (261909-49-3) + 1′-cyano-2′-C-methyl-4-aza-7,9-dideazaadenosine (1191237-49-6) → (2S)-isopropyl 2-((((2R,3R,4R,5R)-5-(4-aminopyrrolo[1,2-f]-[1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphorylamino)propanoate (1350735-57-7)

Conditions	Yield
With 1-methyl-1H-imidazole; trimethyl phosphite In tetrahydrofuran at 0 - 20℃; for 1.5h;	59%
With 1-methyl-1H-imidazole; trimethyl phosphite In tetrahydrofuran at 0 - 20℃; for 1.5h;	59%
With 1-methyl-1H-imidazole; trimethyl phosphite In tetrahydrofuran at 0 - 25℃; for 1.5h;	59%

phenyl(isopropoxy-L-alaninyl) phosphorochloridate (261909-49-3) + C11H13N5O7 → C23H29N6O11P

Conditions	Yield
Stage #1: C11H13N5O7 With tert-butylmagnesium bromide In tetrahydrofuran at 0 - 20℃; for 0.5h; Inert atmosphere; Stage #2: phenyl(isopropoxy-L-alaninyl) phosphorochloridate In tetrahydrofuran at 0 - 20℃; for 20h; Inert atmosphere;	58%

phenyl(isopropoxy-L-alaninyl) phosphorochloridate (261909-49-3) + (3aR,4R,6S,6aS)-4-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-6-fluoro-6-(hydroxymethyl)-2-methoxytetrahydrofuro[3,4-d][1,3]dioxole-4-carbonitrile → isopropyl((((3aS,4S,6R,6aR)-6-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-6-cyano-4-fluoro-2-methoxytetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methoxy)(phenoxy)phosphoryl)-L-alaninate

Conditions	Yield
With 1-methyl-1H-imidazole In acetonitrile at 0 - 20℃; for 1h; Inert atmosphere;	57%

phenyl(isopropoxy-L-alaninyl) phosphorochloridate (261909-49-3) + C22H26N8O3 → propan-2-yl (2S)-2-([phenoxy[(2R)-2-[3-[6-([[4-(piperidine-1-carbonyl)pyridin-2-yl]carbamoyl]amino)pyridin-2-yl]-4H-1,2,4-triazol-4-yl]propoxy]phosphoryl]amino)propanoate

Conditions	Yield
With tert-butylmagnesium chloride In N,N-dimethyl-formamide at -40 - 20℃; for 16h; Inert atmosphere;	56%

phenyl(isopropoxy-L-alaninyl) phosphorochloridate (261909-49-3) + 4-((2-hydroxyethoxy)methyl)-3-oxo-3,4-dihydropyrazine-2-carboxamide → isopropyl ((2-((3-carbamoyl-2-oxopyrazin-1(2H)-yl)methoxy)ethoxy)(phenoxy)phosphoryl)-L-alaninate

Conditions	Yield
Stage #1: 4-((2-hydroxyethoxy)methyl)-3-oxo-3,4-dihydropyrazine-2-carboxamide With pyridine; 1-methyl-1H-imidazole In tetrahydrofuran at 20℃; for 0.333333h; Inert atmosphere; Stage #2: phenyl(isopropoxy-L-alaninyl) phosphorochloridate In tetrahydrofuran at 20℃; Inert atmosphere;	55%

Upstream product

• 770-12-7 O-phenyl phosphorodichloridate 
• 108-95-2 phenol 
• 39825-33-7 isopropyl L-alanine 
• 104-15-4 toluene-4-sulfonic acid 
• 39613-92-8 alanine isopropyl ester hydrochloride 

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