(7R,8R)-2-Chloro-7-hydroxy-8-[3-(4-phenyl-piperazin-1-yl)-propyl]-7,8-dihydro-6H-5-oxa-9-thia-benzocycloheptene-8-carboxylic acid methyl ester; hydrochloride

Base Information

Chemical Name:(7R,8R)-2-Chloro-7-hydroxy-8-[3-(4-phenyl-piperazin-1-yl)-propyl]-7,8-dihydro-6H-5-oxa-9-thia-benzocycloheptene-8-carboxylic acid methyl ester; hydrochloride
CAS No.:99228-69-0
Molecular Formula:C₂₄H₂₉ClN₂O₄S*2ClH
Molecular Weight:549.946
Hs Code.:

(7R,8R)-2-Chloro-7-hydroxy-8-[3-(4-phenyl-piperazin-1-yl)-propyl]-7,8-dihydro-6H-5-oxa-9-thia-benzocycloheptene-8-carboxylic acid methyl ester; hydrochloride

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Chemical Property of (7R,8R)-2-Chloro-7-hydroxy-8-[3-(4-phenyl-piperazin-1-yl)-propyl]-7,8-dihydro-6H-5-oxa-9-thia-benzocycloheptene-8-carboxylic acid methyl ester; hydrochloride

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Technology Process of (7R,8R)-2-Chloro-7-hydroxy-8-[3-(4-phenyl-piperazin-1-yl)-propyl]-7,8-dihydro-6H-5-oxa-9-thia-benzocycloheptene-8-carboxylic acid methyl ester; hydrochloride

There total 10 articles about (7R,8R)-2-Chloro-7-hydroxy-8-[3-(4-phenyl-piperazin-1-yl)-propyl]-7,8-dihydro-6H-5-oxa-9-thia-benzocycloheptene-8-carboxylic acid methyl ester; hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 99228-62-3
methyl 7-chloro-3-oxo-4-[3-(4-phenylpiperazin-1-yl)propyl]-3,4-dihydro-2H-1,5-benzoxathiepin-4-carboxylate

: 99228-69-0,99228-71-4
(7S,8R)-2-Chloro-7-hydroxy-8-[3-(4-phenyl-piperazin-1-yl)-propyl]-7,8-dihydro-6H-5-oxa-9-thia-benzocycloheptene-8-carboxylic acid methyl ester; hydrochloride

: 99228-69-0,99228-71-4
(7R,8R)-2-Chloro-7-hydroxy-8-[3-(4-phenyl-piperazin-1-yl)-propyl]-7,8-dihydro-6H-5-oxa-9-thia-benzocycloheptene-8-carboxylic acid methyl ester; hydrochloride

Guidance literature:: With sodium tetrahydroborate; In tetrahydrofuran; methanol; for 3h;
DOI:10.1248/cpb.35.1930

Reference yield: 46.0%

: 99228-62-3
methyl 7-chloro-3-oxo-4-[3-(4-phenylpiperazin-1-yl)propyl]-3,4-dihydro-2H-1,5-benzoxathiepin-4-carboxylate

: 99228-69-0,99228-71-4
(7S,8R)-2-Chloro-7-hydroxy-8-[3-(4-phenyl-piperazin-1-yl)-propyl]-7,8-dihydro-6H-5-oxa-9-thia-benzocycloheptene-8-carboxylic acid methyl ester; hydrochloride

: 99228-69-0,99228-71-4
(7R,8R)-2-Chloro-7-hydroxy-8-[3-(4-phenyl-piperazin-1-yl)-propyl]-7,8-dihydro-6H-5-oxa-9-thia-benzocycloheptene-8-carboxylic acid methyl ester; hydrochloride

Guidance literature:: With sodium tetrahydroborate; In tetrahydrofuran; methanol; for 3h;
DOI:10.1248/cpb.35.1930

Reference yield:

: 99203-99-3
methyl 7-chloro-3-oxo-3,4-dihydro-2H-1,5-benzoxathiepine-4-carboxylate

: 99228-69-0,99228-71-4
(7S,8R)-2-Chloro-7-hydroxy-8-[3-(4-phenyl-piperazin-1-yl)-propyl]-7,8-dihydro-6H-5-oxa-9-thia-benzocycloheptene-8-carboxylic acid methyl ester; hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: 27 percent / K₂CO₃/KI / acetonitrile / 4 h / Heating

2: 42 percent / NaBH₄ / methanol; tetrahydrofuran / 3 h

With sodium tetrahydroborate; potassium carbonate; potassium iodide; In tetrahydrofuran; methanol; acetonitrile;
DOI:10.1248/cpb.35.1930