1-Phenylpiperazine

Base Information

• Chemical Name: 1-Phenylpiperazine
• CAS No.: 92-54-6
• Deprecated CAS: 123317-04-4
• Molecular Formula: C10H14N2
• Molecular Weight: 162.235
• Hs Code.: 29335995
• European Community (EC) Number: 202-165-6
• UNII: J9225CBI7D
• DSSTox Substance ID: DTXSID8057855
• Nikkaji Number: J35.451A
• Wikipedia: Phenylpiperazine
• Wikidata: Q4862383
• ChEMBL ID: CHEMBL9434
• Mol file: 92-54-6.mol

Synonyms:1-phenylpiperazine;N-phenylpiperazine;phenylpiperazine;phenylpiperazine dihydrobromide;phenylpiperazine dihydrochloride;phenylpiperazine hydrochloride;phenylpiperazine monohydrochloride

Chemical Property of 1-Phenylpiperazine

Chemical Property:

• Appearance/Colour: clear colorless to yellow liquid
• Vapor Pressure: 0.00252mmHg at 25°C
• Melting Point: 18.8 °C
• Refractive Index: 1.588
• Boiling Point: 287.2 °C at 760 mmHg
• PKA: pK1:8.71(+1) (25°C,μ=0.1)
• Flash Point: 138.3 °C
• PSA: 15.27000
• Density: 1.028 g/cm³
• LogP: 1.49000
• Storage Temp.: Store in dark!
• Solubility.: Insoluble
• Water Solubility.: Insoluble
• XLogP3: 1.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 162.115698455
• Heavy Atom Count: 12
• Complexity: 124

Purity/Quality:

99.9% ^*data from raw suppliers

1-Phenylpiperazine >98.0%(GC) ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T, C
• Hazard Codes: T,C
• Statements: 22-24-34-36/37/38-23/24/25
• Safety Statements: 26-36/37/39-45-28A

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C1CN(CCN1)C2=CC=CC=C2

Technology Process of 1-Phenylpiperazine

There total 49 articles about 1-Phenylpiperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

ethyl 3-phenyl-2-(4-tosylpiperazin-1-yl)propanoate (4004-96-0) → 4-phenyl-1-piperazine (92-54-6)

Guidance literature:

With diphenylphosphane; potassium hydroxide; In dimethyl sulfoxide; at 90 ℃; for 1h; Sealed tube; Inert atmosphere;

Reference yield: 98.0%

1-phenylpiperazine hydrochloride (4004-95-9,70849-66-0,2210-93-7) → 4-phenyl-1-piperazine (92-54-6)

Guidance literature:

With sodium hydroxide; In water; for 0.166667h;

Reference yield: 97.0%

4-phenyl-piperazine-1-carboxylic acid tert-butyl ester (77278-63-8) → 4-phenyl-1-piperazine (92-54-6)

Guidance literature:

4-phenyl-piperazine-1-carboxylic acid tert-butyl ester; With trifluoroacetic acid; In dichloromethane; at 30 ℃; for 1h;

With sodium hydroxide; In dichloromethane; water; pH=9;

upstream raw materials:

morpholin hydrochloride

aniline hydrochloride

diethanolamine hydrochloride

bis-(2-chloroethyl)amine hydrochloride

Downstream raw materials:

2-(4-phenyl-piperazin-1-ylsulfanyl)-benzothiazole

1-methoxy-3-(4-phenyl-piperazin-1-yl)-propan-2-ol

4-(N⁴-Phenyl-N¹-piperazinyl)-2,3-trimethylenequinoline

(2H-Chromen-3-yl)-(4-phenyl-piperazin-1-yl)-methanone

Refernces

• 1、 -. "MONOACYLGLYCEROL LIPASE INHIBITORS". Paragraph 0111-0112; 0141; 0153-0154. . Retrieved 2021/09/09.
• 2、 Liu, Xin,Werner, Thomas. "Indirect reduction of CO2and recycling of polymers by manganese-catalyzed transfer hydrogenation of amides, carbamates, urea derivatives, and polyurethanes". . p. 10590 - 10597. Retrieved 2021/08/20.