((2R,3S,5R)-5-(8-(3-acetylphenyl)-2-amino-6-oxo-1H-purin-9(6H)-yl)-3-(4-(1-(7-hydroxy-2-oxo-2H-chromen-3-yl)-1H-1,2,3-triazol-4-yl)butanoyloxy)tetrahydrofuran-2-yl)methyl 6-(4-((dimethylamino)methyl)-1H-1,2,3-triazol-1-yl)hexanoate

Base Information

Chemical Name:((2R,3S,5R)-5-(8-(3-acetylphenyl)-2-amino-6-oxo-1H-purin-9(6H)-yl)-3-(4-(1-(7-hydroxy-2-oxo-2H-chromen-3-yl)-1H-1,2,3-triazol-4-yl)butanoyloxy)tetrahydrofuran-2-yl)methyl 6-(4-((dimethylamino)methyl)-1H-1,2,3-triazol-1-yl)hexanoate
CAS No.:1398108-97-8
Molecular Formula:C₄₄H₄₈N₁₂O₁₀
Molecular Weight:904.94
Hs Code.:

((2R,3S,5R)-5-(8-(3-acetylphenyl)-2-amino-6-oxo-1H-purin-9(6H)-yl)-3-(4-(1-(7-hydroxy-2-oxo-2H-chromen-3-yl)-1H-1,2,3-triazol-4-yl)butanoyloxy)tetrahydrofuran-2-yl)methyl 6-(4-((dimethylamino)methyl)-1H-1,2,3-triazol-1-yl)hexanoate

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Chemical Property of ((2R,3S,5R)-5-(8-(3-acetylphenyl)-2-amino-6-oxo-1H-purin-9(6H)-yl)-3-(4-(1-(7-hydroxy-2-oxo-2H-chromen-3-yl)-1H-1,2,3-triazol-4-yl)butanoyloxy)tetrahydrofuran-2-yl)methyl 6-(4-((dimethylamino)methyl)-1H-1,2,3-triazol-1-yl)hexanoate

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Technology Process of ((2R,3S,5R)-5-(8-(3-acetylphenyl)-2-amino-6-oxo-1H-purin-9(6H)-yl)-3-(4-(1-(7-hydroxy-2-oxo-2H-chromen-3-yl)-1H-1,2,3-triazol-4-yl)butanoyloxy)tetrahydrofuran-2-yl)methyl 6-(4-((dimethylamino)methyl)-1H-1,2,3-triazol-1-yl)hexanoate

There total 7 articles about ((2R,3S,5R)-5-(8-(3-acetylphenyl)-2-amino-6-oxo-1H-purin-9(6H)-yl)-3-(4-(1-(7-hydroxy-2-oxo-2H-chromen-3-yl)-1H-1,2,3-triazol-4-yl)butanoyloxy)tetrahydrofuran-2-yl)methyl 6-(4-((dimethylamino)methyl)-1H-1,2,3-triazol-1-yl)hexanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1398108-98-9
8-(3-acetylphenyl)-2-amino-9-((2R,4S,5R)-5-((tertbutyldimethylsilyloxy)methyl)-4-hydroxytetrahydrofuran-2-yl)-1H-purin-6(9H)-one

: 1398108-97-8
((2R,3S,5R)-5-(8-(3-acetylphenyl)-2-amino-6-oxo-1H-purin-9(6H)-yl)-3-(4-(1-(7-hydroxy-2-oxo-2H-chromen-3-yl)-1H-1,2,3-triazol-4-yl)butanoyloxy)tetrahydrofuran-2-yl)methyl 6-(4-((dimethylamino)methyl)-1H-1,2,3-triazol-1-yl)hexanoate

Guidance literature:: Multi-step reaction with 6 steps

1.1: toluene-4-sulfonic acid; dmap / N,N-dimethyl-formamide / 1 h / Inert atmosphere

1.2: 20 °C / Inert atmosphere

2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 °C / Inert atmosphere

3.1: toluene-4-sulfonic acid; dicyclohexyl-carbodiimide / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

4.1: sodium L-ascorbate; copper(II) sulphate hydrate / tetrahydrofuran; water

5.1: sodium azide / N,N-dimethyl-formamide / 80 °C / Inert atmosphere

6.1: sodium L-ascorbate; copper(II) sulphate hydrate / tetrahydrofuran / pH 7.4

With dmap; sodium azide; copper(II) sulphate hydrate; tetrabutyl ammonium fluoride; toluene-4-sulfonic acid; sodium L-ascorbate; dicyclohexyl-carbodiimide; In tetrahydrofuran; water; N,N-dimethyl-formamide;
DOI:10.1039/c2ob25913c

Reference yield:

: C₂₄H₂₅N₅O₆

: 1398108-97-8
((2R,3S,5R)-5-(8-(3-acetylphenyl)-2-amino-6-oxo-1H-purin-9(6H)-yl)-3-(4-(1-(7-hydroxy-2-oxo-2H-chromen-3-yl)-1H-1,2,3-triazol-4-yl)butanoyloxy)tetrahydrofuran-2-yl)methyl 6-(4-((dimethylamino)methyl)-1H-1,2,3-triazol-1-yl)hexanoate

Guidance literature:: Multi-step reaction with 4 steps

1: toluene-4-sulfonic acid; dicyclohexyl-carbodiimide / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

2: sodium L-ascorbate; copper(II) sulphate hydrate / tetrahydrofuran; water

3: sodium azide / N,N-dimethyl-formamide / 80 °C / Inert atmosphere

4: sodium L-ascorbate; copper(II) sulphate hydrate / tetrahydrofuran / pH 7.4

With sodium azide; copper(II) sulphate hydrate; toluene-4-sulfonic acid; sodium L-ascorbate; dicyclohexyl-carbodiimide; In tetrahydrofuran; water; N,N-dimethyl-formamide;
DOI:10.1039/c2ob25913c

Reference yield:

: 4224-70-8
6-bromohexanoic acid

: 1398108-97-8
((2R,3S,5R)-5-(8-(3-acetylphenyl)-2-amino-6-oxo-1H-purin-9(6H)-yl)-3-(4-(1-(7-hydroxy-2-oxo-2H-chromen-3-yl)-1H-1,2,3-triazol-4-yl)butanoyloxy)tetrahydrofuran-2-yl)methyl 6-(4-((dimethylamino)methyl)-1H-1,2,3-triazol-1-yl)hexanoate

Guidance literature:: Multi-step reaction with 4 steps

1: toluene-4-sulfonic acid; dicyclohexyl-carbodiimide / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

2: sodium L-ascorbate; copper(II) sulphate hydrate / tetrahydrofuran; water

3: sodium azide / N,N-dimethyl-formamide / 80 °C / Inert atmosphere

4: sodium L-ascorbate; copper(II) sulphate hydrate / tetrahydrofuran / pH 7.4

With sodium azide; copper(II) sulphate hydrate; toluene-4-sulfonic acid; sodium L-ascorbate; dicyclohexyl-carbodiimide; In tetrahydrofuran; water; N,N-dimethyl-formamide;
DOI:10.1039/c2ob25913c