Trifluoro-methanesulfonic acid 5-[3-{2-[1-(tert-butyl-dimethyl-silanyloxy)-prop-2-ynyl]-5-methoxy-phenyl}-prop-2-yn-(Z)-ylidene]-cyclopent-1-enyl ester

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Chemical Name:Trifluoro-methanesulfonic acid 5-[3-{2-[1-(tert-butyl-dimethyl-silanyloxy)-prop-2-ynyl]-5-methoxy-phenyl}-prop-2-yn-(Z)-ylidene]-cyclopent-1-enyl ester
CAS No.:179129-18-1
Molecular Formula:C₂₅H₂₉F₃O₅SSi
Molecular Weight:526.649
Hs Code.:

Trifluoro-methanesulfonic acid 5-[3-{2-[1-(tert-butyl-dimethyl-silanyloxy)-prop-2-ynyl]-5-methoxy-phenyl}-prop-2-yn-(Z)-ylidene]-cyclopent-1-enyl ester

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Chemical Property of Trifluoro-methanesulfonic acid 5-[3-{2-[1-(tert-butyl-dimethyl-silanyloxy)-prop-2-ynyl]-5-methoxy-phenyl}-prop-2-yn-(Z)-ylidene]-cyclopent-1-enyl ester

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Technology Process of Trifluoro-methanesulfonic acid 5-[3-{2-[1-(tert-butyl-dimethyl-silanyloxy)-prop-2-ynyl]-5-methoxy-phenyl}-prop-2-yn-(Z)-ylidene]-cyclopent-1-enyl ester

There total 9 articles about Trifluoro-methanesulfonic acid 5-[3-{2-[1-(tert-butyl-dimethyl-silanyloxy)-prop-2-ynyl]-5-methoxy-phenyl}-prop-2-yn-(Z)-ylidene]-cyclopent-1-enyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 69739-34-0
t-butyldimethylsiyl triflate

: 179129-17-0
(Z)-<5-<3-<2-<1-Hydroxy-2-propynyl>-5-methoxyphenyl>-2-propynylidene>-1-cyclopenten-1-yl> trifluoromethanesulfonate

: 179129-18-1
Trifluoro-methanesulfonic acid 5-[3-{2-[1-(tert-butyl-dimethyl-silanyloxy)-prop-2-ynyl]-5-methoxy-phenyl}-prop-2-yn-(Z)-ylidene]-cyclopent-1-enyl ester

Guidance literature:: With triethylamine; In dichloromethane; 1.) r.t., 25 min, 2.) r.t., 5 min;

Reference yield:

: 105469-13-4
2-iodo-4-methoxybenzaldehyde

: 179129-18-1
Trifluoro-methanesulfonic acid 5-[3-{2-[1-(tert-butyl-dimethyl-silanyloxy)-prop-2-ynyl]-5-methoxy-phenyl}-prop-2-yn-(Z)-ylidene]-cyclopent-1-enyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 95 percent / Et₃N / Pd(PPh₃)2Cl₂, CuI / benzene / 0.17 h / Ambient temperature

2: 90 percent / K₂CO₃ / methanol / 0.33 h / 0 °C

3: 82 percent / n-BuLi / tetrahydrofuran; hexane / -78 °C

4: 66 percent / i-Pr₂NH / Pd(PPh₃)2Cl₂, CuI / benzene / 2.5 h / Ambient temperature

5: 85 percent / 45percent aq. NH₄F, n-Bu₄NHSO₄ / CH₂Cl₂ / 1.5 h / 20 °C

6: 76 percent / Et₃N / CH₂Cl₂ / 1.) r.t., 25 min, 2.) r.t., 5 min

With ammonium fluoride; n-butyllithium; tetra(n-butyl)ammonium hydrogensulfate; potassium carbonate; triethylamine; diisopropylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In tetrahydrofuran; methanol; hexane; dichloromethane; benzene;

Reference yield:

: 2186-92-7
p-Anisaldehyde dimethyl acetal

: 179129-18-1
Trifluoro-methanesulfonic acid 5-[3-{2-[1-(tert-butyl-dimethyl-silanyloxy)-prop-2-ynyl]-5-methoxy-phenyl}-prop-2-yn-(Z)-ylidene]-cyclopent-1-enyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: t-BuLi, I₂ / diethyl ether; pentane / 1.) -25 deg C, 6 h, 2.) r.t., 2 h

2: 2 N aq. HCl / 12 h / Ambient temperature

3: 95 percent / Et₃N / Pd(PPh₃)2Cl₂, CuI / benzene / 0.17 h / Ambient temperature

4: 90 percent / K₂CO₃ / methanol / 0.33 h / 0 °C

5: 82 percent / n-BuLi / tetrahydrofuran; hexane / -78 °C

6: 66 percent / i-Pr₂NH / Pd(PPh₃)2Cl₂, CuI / benzene / 2.5 h / Ambient temperature

7: 85 percent / 45percent aq. NH₄F, n-Bu₄NHSO₄ / CH₂Cl₂ / 1.5 h / 20 °C

8: 76 percent / Et₃N / CH₂Cl₂ / 1.) r.t., 25 min, 2.) r.t., 5 min

With hydrogenchloride; ammonium fluoride; n-butyllithium; iodine; tert.-butyl lithium; tetra(n-butyl)ammonium hydrogensulfate; potassium carbonate; triethylamine; diisopropylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In tetrahydrofuran; methanol; diethyl ether; hexane; dichloromethane; pentane; benzene;