(trans)-ethyl 1-((2S,4R)-1-((S)-2-((S)-2-(((tert-butoxy)carbonyl)amino)-2-cyclohexylacetamido)-3-methylbutanoyl)-4-hydroxypyrrolidine-2-carboxamido)-2-vinylcyclopropanecarboxylate

Base Information

Chemical Name:(trans)-ethyl 1-((2S,4R)-1-((S)-2-((S)-2-(((tert-butoxy)carbonyl)amino)-2-cyclohexylacetamido)-3-methylbutanoyl)-4-hydroxypyrrolidine-2-carboxamido)-2-vinylcyclopropanecarboxylate
CAS No.:1439898-68-6
Molecular Formula:C₃₁H₅₀N₄O₈
Molecular Weight:606.76
Hs Code.:

(trans)-ethyl 1-((2S,4R)-1-((S)-2-((S)-2-(((tert-butoxy)carbonyl)amino)-2-cyclohexylacetamido)-3-methylbutanoyl)-4-hydroxypyrrolidine-2-carboxamido)-2-vinylcyclopropanecarboxylate

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Chemical Property of (trans)-ethyl 1-((2S,4R)-1-((S)-2-((S)-2-(((tert-butoxy)carbonyl)amino)-2-cyclohexylacetamido)-3-methylbutanoyl)-4-hydroxypyrrolidine-2-carboxamido)-2-vinylcyclopropanecarboxylate

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Technology Process of (trans)-ethyl 1-((2S,4R)-1-((S)-2-((S)-2-(((tert-butoxy)carbonyl)amino)-2-cyclohexylacetamido)-3-methylbutanoyl)-4-hydroxypyrrolidine-2-carboxamido)-2-vinylcyclopropanecarboxylate

There total 5 articles about (trans)-ethyl 1-((2S,4R)-1-((S)-2-((S)-2-(((tert-butoxy)carbonyl)amino)-2-cyclohexylacetamido)-3-methylbutanoyl)-4-hydroxypyrrolidine-2-carboxamido)-2-vinylcyclopropanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 13726-69-7,946610-68-0
(2S,4R)-4-hydroxy-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carboxylic acid

: 1439898-68-6
(trans)-ethyl 1-((2S,4R)-1-((S)-2-((S)-2-(((tert-butoxy)carbonyl)amino)-2-cyclohexylacetamido)-3-methylbutanoyl)-4-hydroxypyrrolidine-2-carboxamido)-2-vinylcyclopropanecarboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0 - 20 °C

2: hydrogenchloride / water; 1,4-dioxane / 0.42 h / 20 °C

3: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0 - 20 °C

4: hydrogenchloride / water; 1,4-dioxane / 0.42 h / 20 °C

5: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0 - 20 °C

With hydrogenchloride; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In 1,4-dioxane; water; N,N-dimethyl-formamide;
DOI:10.1021/jm400164c

Reference yield:

: 1439898-66-4
C₁₃H₂₀N₂O₄

: 1439898-68-6
(trans)-ethyl 1-((2S,4R)-1-((S)-2-((S)-2-(((tert-butoxy)carbonyl)amino)-2-cyclohexylacetamido)-3-methylbutanoyl)-4-hydroxypyrrolidine-2-carboxamido)-2-vinylcyclopropanecarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0 - 20 °C

2: hydrogenchloride / water; 1,4-dioxane / 0.42 h / 20 °C

3: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0 - 20 °C

With hydrogenchloride; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In 1,4-dioxane; water; N,N-dimethyl-formamide;
DOI:10.1021/jm400164c

Reference yield:

: 669008-08-6
(2S,4R)-tert-butyl 2-((trans)-1-(ethoxycarbonyl)-2-vinylcyclopropylcarbamoyl)-4-hydroxypyrrolidine-1-carboxylate

: 1439898-68-6
(trans)-ethyl 1-((2S,4R)-1-((S)-2-((S)-2-(((tert-butoxy)carbonyl)amino)-2-cyclohexylacetamido)-3-methylbutanoyl)-4-hydroxypyrrolidine-2-carboxamido)-2-vinylcyclopropanecarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogenchloride / water; 1,4-dioxane / 0.42 h / 20 °C

2: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0 - 20 °C

3: hydrogenchloride / water; 1,4-dioxane / 0.42 h / 20 °C

4: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0 - 20 °C

With hydrogenchloride; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In 1,4-dioxane; water; N,N-dimethyl-formamide;
DOI:10.1021/jm400164c