Technology Process of 2-methyl-2-(phenylethynyl)pent-4-enal
There total 6 articles about 2-methyl-2-(phenylethynyl)pent-4-enal which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione;
In
dimethyl sulfoxide;
at 20 ℃;
DOI:10.1002/anie.201405215
- Guidance literature:
-
Multi-step reaction with 6 steps
1: sodium hydride / tetrahydrofuran
2: pyridinium chlorochromate / dichloromethane / 20 °C
3: potassium carbonate / methanol / 20 °C
4: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / 10 h / 20 °C / Inert atmosphere
5: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 °C
6: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / dimethyl sulfoxide / 20 °C
With
bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; tetrabutyl ammonium fluoride; sodium hydride; potassium carbonate; triethylamine; pyridinium chlorochromate; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione;
In
tetrahydrofuran; methanol; dichloromethane; dimethyl sulfoxide;
DOI:10.1002/anie.201405215
- Guidance literature:
-
Multi-step reaction with 5 steps
1: pyridinium chlorochromate / dichloromethane / 20 °C
2: potassium carbonate / methanol / 20 °C
3: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / 10 h / 20 °C / Inert atmosphere
4: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 °C
5: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / dimethyl sulfoxide / 20 °C
With
bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; tetrabutyl ammonium fluoride; potassium carbonate; triethylamine; pyridinium chlorochromate; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione;
In
tetrahydrofuran; methanol; dichloromethane; dimethyl sulfoxide;
DOI:10.1002/anie.201405215
