Technology Process of ACY-1083
There total 6 articles about ACY-1083 which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
hydroxylamine; sodium hydroxide;
In
methanol; dichloromethane; water;
at 0 - 25 ℃;
for 18h;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: titanium(IV) tetraethanolate / tetrahydrofuran / 16 h / 55 °C
2.1: tetrahydrofuran / 0 - 20 °C
2.2: pH 6-7
3.1: hydrogenchloride / water; tetrahydrofuran / 16 h / 50 °C
4.1: N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 5 h / 130 °C
5.1: diethylamino-sulfur trifluoride / dichloromethane / 5 h / 0 - 35 °C
6.1: sodium hydroxide; hydroxylamine / water; dichloromethane; methanol / 18 h / 0 - 25 °C
With
hydrogenchloride; titanium(IV) tetraethanolate; diethylamino-sulfur trifluoride; hydroxylamine; N-ethyl-N,N-diisopropylamine; sodium hydroxide;
In
tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; dichloromethane; water;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: tetrahydrofuran / 0 - 20 °C
1.2: pH 6-7
2.1: hydrogenchloride / water; tetrahydrofuran / 16 h / 50 °C
3.1: N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 5 h / 130 °C
4.1: diethylamino-sulfur trifluoride / dichloromethane / 5 h / 0 - 35 °C
5.1: sodium hydroxide; hydroxylamine / water; dichloromethane; methanol / 18 h / 0 - 25 °C
With
hydrogenchloride; diethylamino-sulfur trifluoride; hydroxylamine; N-ethyl-N,N-diisopropylamine; sodium hydroxide;
In
tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; dichloromethane; water;
