3-Pyridinecarbonitrile, 6-methyl-2-(4-morpholiny

Base Information

• Chemical Name: 3-Pyridinecarbonitrile, 6-methyl-2-(4-morpholiny
• CAS No.: 108611-26-3
• Molecular Formula: C₁₇H₁₇N₃O
• Molecular Weight: 279.341
• DSSTox Substance ID: DTXSID10878156
• Nikkaji Number: J1.555.941A
• Wikidata: Q82860121
• Mol file: 108611-26-3.mol

Synonyms:108611-26-3;SCHEMBL7282590;DTXSID10878156;3-PYRIDINECARBONITRILE, 6-METHYL-2-(4-MORPHOLINY

Chemical Property of 3-Pyridinecarbonitrile, 6-methyl-2-(4-morpholiny

Chemical Property:

• XLogP3: 2.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 279.137162174
• Heavy Atom Count: 21
• Complexity: 379

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC1=C(C=C(C(=N1)N2CCOCC2)C#N)C3=CC=CC=C3

Technology Process of 3-Pyridinecarbonitrile, 6-methyl-2-(4-morpholiny

There total 2 articles about 3-Pyridinecarbonitrile, 6-methyl-2-(4-morpholiny which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

morpholine (110-91-8,99108-56-2) + 2-Chlor-3-cyan-6-methyl-5-phenylpyridin (10176-63-3) → 6-Methyl-2-morpholin-4-yl-5-phenyl-nicotinonitrile (108611-26-3)

Guidance literature:

In ethanol; for 8h; Heating;

Reference yield:

6-methyl-5-phenylpyrid-2-one-3-carbonitrile (4241-12-7) → 6-Methyl-2-morpholin-4-yl-5-phenyl-nicotinonitrile (108611-26-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 44 percent / POCl₃ / dimethylformamide / 8 h / Heating

2: 88 percent / ethanol / 8 h / Heating

With trichlorophosphate; In ethanol; N,N-dimethyl-formamide;

upstream raw materials:

morpholine

2-Chlor-3-cyan-6-methyl-5-phenylpyridin

6-methyl-5-phenylpyrid-2-one-3-carbonitrile

Refernces