Methyl 4,5-dihydroxy-7-methoxy-3-(methoxycarbonyl)-2-naphthaleneacetate

Base Information

Chemical Name:Methyl 4,5-dihydroxy-7-methoxy-3-(methoxycarbonyl)-2-naphthaleneacetate
CAS No.:127983-37-3
Molecular Formula:C₁₆H₁₆O₇
Molecular Weight:320.299
Hs Code.:
DSSTox Substance ID:DTXSID401152559
Nikkaji Number:J1.262.202C

Synonyms:DTXSID401152559;127983-37-3;Methyl 4,5-dihydroxy-7-methoxy-3-(methoxycarbonyl)-2-naphthaleneacetate

Suppliers and Price of Methyl 4,5-dihydroxy-7-methoxy-3-(methoxycarbonyl)-2-naphthaleneacetate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Methyl 4,5-dihydroxy-7-methoxy-3-(methoxycarbonyl)-2-naphthaleneacetate

Chemical Property:

XLogP3:2.6
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:6
Exact Mass:320.08960285
Heavy Atom Count:23
Complexity:438

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:COC1=CC(=C2C(=C1)C=C(C(=C2O)C(=O)OC)CC(=O)OC)O

Technology Process of Methyl 4,5-dihydroxy-7-methoxy-3-(methoxycarbonyl)-2-naphthaleneacetate

There total 1 articles about Methyl 4,5-dihydroxy-7-methoxy-3-(methoxycarbonyl)-2-naphthaleneacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 9.0%

: 1712-36-3
penta-2,3-dienedioic acid dimethyl ester

: 267662-49-7
8-hydroxy-6-methoxy-1H-2-benzopyran-1,3(4H)-dione

: 127983-37-3
methyl (4,5-dihydroxy-7-methoxy-3-methoxycarbonylnaphthalen-2-yl)acetate

: 267662-48-6
(2-carboxy-3-hydroxy-5-methoxyphenyl)acetic acid

Guidance literature:: 8-hydroxy-6-methoxy-1H-2-benzopyran-1,3(4H)-dione; With sodium hydride; In tetrahydrofuran; at 0 ℃; for 0.166667h;

penta-2,3-dienedioic acid dimethyl ester; In tetrahydrofuran; at 0 - 20 ℃; for 2.33333h;

With hydrogenchloride; In tetrahydrofuran; for 0.5h;
DOI:10.1071/CH99065

Reference yield:

: 127983-37-3
methyl (4,5-dihydroxy-7-methoxy-3-methoxycarbonylnaphthalen-2-yl)acetate

: 70477-26-8
Semivioxanthin

Guidance literature:: Multi-step reaction with 4 steps

1: 1) LDA / 2) THF, -78 deg C - 0 deg C

2: TFA / CH₂Cl₂ / Ambient temperature

3: tetrahydrofuran / 0.5 h / Heating

4: 51 percent / NaBH₄ / ethanol / 1 h / -78 °C

With sodium tetrahydroborate; trifluoroacetic acid; lithium diisopropyl amide; In tetrahydrofuran; ethanol; dichloromethane;