1712-36-3

Upstream product

• 67-56-1 methanol 
• 33406-97-2 2,4,6-Tris(diazo)-1,3,5-cyclohexantrione 
• 1830-54-2 3-oxopentanedioic acid dimethyl ester 
• 120461-65-6 dimethyl 3-chloro-2-pentenedioate 
• 186581-53-3 diazomethane 
• 32804-68-5 1,3-allenedicarboxylic acid 

Downstream Products

• 86844-23-7 4-carboxy-1-phenyl-1,2,3-triazole-5-acetic acid 
• 1214-87-5 methyl (2-carbomethoxy-3-methoxyphenyl)acetate 
• 93953-37-8 methyl 2-carbomethoxy-3-methoxy-5-methylbenzene-1-acetate 
• 82325-23-3 dimethyl 3-(anilino)pent-2-enedioate 
• 96237-68-2 tetramethyl (E,E)-3,3'-(1,4-phenylenedioxy)bispent-2-enedioate 
• 96237-65-9 dimethyl (E)-3-phenoxypent-2-enedioate 
• 214116-44-6 (Z)-3-[Bis-(2-chloro-ethyl)-amino]-pent-2-enedioic acid dimethyl ester 
• 127983-37-3 methyl (4,5-dihydroxy-7-methoxy-3-methoxycarbonylnaphthalen-2-yl)acetate 
• 267662-48-6 (2-carboxy-3-hydroxy-5-methoxyphenyl)acetic acid 
• 100118-53-4 methyl 2-hydroxy-4-methoxy-6-(methoxycarbonylmethyl)benzoate 
• 6512-26-1 methyl 2,4-dimethoxy-6-(methoxycarbonylmethyl)benzoate 
• 138832-01-6 (2S,3R)-1-Benzyl-2-methoxycarbonylmethyl-2,3-dihydro-1H-indole-3-carboxylic acid methyl ester 

Relevant academic research and scientific papers

HSP90 FAMILY PROTEIN INHIBITORS

The present invention provides Hsp90 family protein inhibitors comprising, as an active ingredient, a benzoic acid derivative represented by General Formula (I): [wherein n represents an integer of 0 to 10; R1 represents substituted or unsubsti

A practical improvement of crystallization-induced asymmetric transformation of allene-1,3-dicarboxylates

Enantiomerically pure allene-1,3-dicarboxylates were easily synthesized by using epimerization-crystallization of dissymmetric allene compounds, which were prepared from acetone-1,3-dicarboxylates and naturally abundant chiral alcohols, that is, (-)- and

Total Synthesis of Premithramycinone H and Related Anthrapyran Antibiotics

Two approaches are described for the preparation of 2-(1',3'-dioxoalkyl)-substituted 1-hydroxyanthraquinones 10a-d and 20a-c, which were cyclized in a biomimetic-type reaction to the anthra[1,2-b]pyran skeletons 11a-d and 21a-c of the heydamcin- or pluram

Reactions of the Lithium Salts of the Tribenzylidenemethane Dianion, Diphenylacetone Dianion, and Related Compounds

Potentially synthetically useful reactions of the dilithium salts of the title dianions have been investigated. Electrophilic quenching with a variety of reagents usually leads to the expected products in good yield. Quenching the diphenylacetone dianion with 1 equiv of trimethylchlorosilane, however, gives a good yield of 1,3-diphenylallene obtained by formal elimination of a trimethylsiloxy anion from an intermediate monoquenched monoanion salt. NMR studies, however, do not reveal the intermediacy of the 1,3-diphenyl-2-(trimethylsiloxy)allyl anion but rather suggest that the initial reaction site is at carbon, rather than oxygen. Oxidation of the dianions leads either to ring closure or dimerization for the tribenzylidenemethane dianion and to dimerization for the diphenylacetone dianion. The dimerization reactions are stereospecific, both with respect to the two new stereocenters produced and for the double bonds of the bis-silyl enol ether products if the dimeric bis-enolate dianion products are quenched with trimethylchlorosilane.

A new synthetic method for allene-1,3-dicarboxylates using DMC and a novel tandem cyclization to a pyrrolizidine alkaloid skeleton

A new one-step synthesis of allene-1,3-dicarboxylates from acetone-1,3- dicarboxylates in high yields was developed by the use of DMC as a dehydrating reagent. This process opened a new expeditious mute to a 1- azabicyclo[3.3.0]octane skeleton of pyrrolizidine alkaloids from dimethyl acetone-1,3-dicarboxylate and bis(2-chloroethyl)amine via a Michael addition and a novel tandem cyclization.