(2S,3S)-4-(4-chlorobenzylamino)-2,3-methano-1-(1H-imidazol-4-yl)butane

Base Information

Chemical Name:(2S,3S)-4-(4-chlorobenzylamino)-2,3-methano-1-(1H-imidazol-4-yl)butane
CAS No.:1355254-38-4
Molecular Formula:C₁₅H₁₈ClN₃
Molecular Weight:275.781
Hs Code.:

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S,3S)-4-(4-chlorobenzylamino)-2,3-methano-1-(1H-imidazol-4-yl)butane

Chemical Property:

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Technology Process of (2S,3S)-4-(4-chlorobenzylamino)-2,3-methano-1-(1H-imidazol-4-yl)butane

There total 10 articles about (2S,3S)-4-(4-chlorobenzylamino)-2,3-methano-1-(1H-imidazol-4-yl)butane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₅₃H₄₆ClN₃

: 1355254-38-4
(2S,3S)-4-(4-chlorobenzylamino)-2,3-methano-1-(1H-imidazol-4-yl)butane

Guidance literature:: C₅₃H₄₆ClN₃; With hydrogenchloride; In ethanol; water; at 78 ℃; for 2h;

With sodium hydroxide; In ethanol; dichloromethane; water;
DOI:10.1039/c1ob06496g

Reference yield:

: 1046470-60-3
(1S,2S)-2-[(tert-butyldiphenylsiloxy)methyl]-1-(formylmethyl)cyclopropane

: 1355254-38-4
(2S,3S)-4-(4-chlorobenzylamino)-2,3-methano-1-(1H-imidazol-4-yl)butane

Guidance literature:: Multi-step reaction with 8 steps

1: sodium cyanide / ethanol / 0.5 h / 0 °C / Inert atmosphere

2: ammonia / ethanol / 24 h / 120 °C / Inert atmosphere; Saturated solution

3: pyridine / 12 h / 20 °C / Inert atmosphere

4: tetrabutyl ammonium fluoride / tetrahydrofuran / 12 h / 20 °C / Inert atmosphere

5: Dess-Martin periodane / dichloromethane / 2 h / 20 °C / Inert atmosphere

6: 2-picoline borane complex; acetic acid / methanol / 8 h / 20 °C / Inert atmosphere

7: triethylamine / dichloromethane / 12 h / 20 °C / Inert atmosphere

8: hydrogenchloride / ethanol; water / 2 h / 78 °C

With pyridine; hydrogenchloride; sodium cyanide; 2-picoline borane complex; tetrabutyl ammonium fluoride; ammonia; Dess-Martin periodane; acetic acid; triethylamine; In tetrahydrofuran; methanol; ethanol; dichloromethane; water;
DOI:10.1039/c1ob06496g

Reference yield:

: 1355254-24-8
(2S,3S)-4-tert-butyldiphenylsilyloxy-2,3-methano-1-(1-triphenylmethyl-1H-imidazol-4-yl)butane

: 1355254-38-4
(2S,3S)-4-(4-chlorobenzylamino)-2,3-methano-1-(1H-imidazol-4-yl)butane

Guidance literature:: Multi-step reaction with 5 steps

1: tetrabutyl ammonium fluoride / tetrahydrofuran / 12 h / 20 °C / Inert atmosphere

2: Dess-Martin periodane / dichloromethane / 2 h / 20 °C / Inert atmosphere

3: 2-picoline borane complex; acetic acid / methanol / 8 h / 20 °C / Inert atmosphere

4: triethylamine / dichloromethane / 12 h / 20 °C / Inert atmosphere

5: hydrogenchloride / ethanol; water / 2 h / 78 °C

With hydrogenchloride; 2-picoline borane complex; tetrabutyl ammonium fluoride; Dess-Martin periodane; acetic acid; triethylamine; In tetrahydrofuran; methanol; ethanol; dichloromethane; water;
DOI:10.1039/c1ob06496g