Technology Process of methyl 4-(2,5-difluoro-3-methoxyphenyl)-3,4,5,6-tetrahydro-2H-pyran-4-carboxylate
There total 10 articles about methyl 4-(2,5-difluoro-3-methoxyphenyl)-3,4,5,6-tetrahydro-2H-pyran-4-carboxylate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
methyl 2,5-difluoro-3-methoxyphenylacetate;
With
15-crown-5; sodium hydride;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 0.666667h;
3-oxa-1,5-dichloropentane;
With
sodium iodide;
In
N,N-dimethyl-formamide;
for 10.5h;
DOI:10.1248/cpb.53.965
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: 95 percent / NaBH4 / ethanol / 0.5 h / 20 °C
2.1: Et3N / CH2Cl2 / 3.5 h / 20 °C
3.1: 5.91 g / dimethylsulfoxide / 2 h
4.1: KOH / ethane-1,2-diol / 1 h / 120 °C
5.1: 3.80 g / H2SO4 / 1 h / Heating
6.1: NaH; 15-crown-5 / dimethylformamide / 0.67 h / 20 °C
6.2: NaI / dimethylformamide / 10.5 h
With
potassium hydroxide; sodium tetrahydroborate; 15-crown-5; sulfuric acid; sodium hydride; triethylamine;
In
ethanol; dichloromethane; ethylene glycol; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1248/cpb.53.965
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: Et3N / CH2Cl2 / 3.5 h / 20 °C
2.1: 5.91 g / dimethylsulfoxide / 2 h
3.1: KOH / ethane-1,2-diol / 1 h / 120 °C
4.1: 3.80 g / H2SO4 / 1 h / Heating
5.1: NaH; 15-crown-5 / dimethylformamide / 0.67 h / 20 °C
5.2: NaI / dimethylformamide / 10.5 h
With
potassium hydroxide; 15-crown-5; sulfuric acid; sodium hydride; triethylamine;
In
dichloromethane; ethylene glycol; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1248/cpb.53.965
