3-amino-4-hydroxyphenyl-2-methylacetic acid

Base Information

• Chemical Name: 3-amino-4-hydroxyphenyl-2-methylacetic acid
• CAS No.: 51234-43-6
• Molecular Formula: C₉H₁₁NO₃
• Molecular Weight: 181.191
• Mol file: 51234-43-6.mol

Synonyms:

Chemical Property of 3-amino-4-hydroxyphenyl-2-methylacetic acid

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-amino-4-hydroxyphenyl-2-methylacetic acid

There total 6 articles about 3-amino-4-hydroxyphenyl-2-methylacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.2%

3-Nitro-4-hydroxyphenyl-α-methylacetic acid (65784-32-9,73933-14-9,90103-59-6) → 3-amino-4-hydroxyphenyl-2-methylacetic acid (51234-43-6,73933-15-0)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; at 20 ℃; for 3h; under 2327.23 Torr;

Reference yield:

2-(4-hydroxyphenyl)propanenitrile (21850-61-3) → 3-amino-4-hydroxyphenyl-2-methylacetic acid (51234-43-6,73933-15-0)

Guidance literature:

Multi-step reaction with 3 steps

1: HNO₃ / acetic acid

2: SnCl₂, aq. HCl / ethanol

3: aq. HCl / Heating

With hydrogenchloride; nitric acid; tin(ll) chloride; In ethanol; acetic acid;

DOI:10.1021/jm00235a012

Reference yield:

3-nitro-4-hydroxyphenyl-α-methyl-acetonitrile (51234-22-1,66934-21-2) → 3-amino-4-hydroxyphenyl-2-methylacetic acid (51234-43-6,73933-15-0)

Guidance literature:

Multi-step reaction with 2 steps

1: SnCl₂, aq. HCl / ethanol

2: aq. HCl / Heating

With hydrogenchloride; tin(ll) chloride; In ethanol;

DOI:10.1021/jm00235a012

upstream raw materials:

2-(3-amino-4-hydroxyphenyl)-propionitrile

2-(4-hydroxyphenyl)propanenitrile

3-nitro-4-hydroxyphenyl-α-methyl-acetonitrile

2-(4-aminophenyl)-propionitrile

Downstream raw materials:

2-[2-(2-chloro-phenyl)-benzooxazol-5-yl]-propionic acid

2-[2-(3-trifluoromethyl-phenyl)-benzooxazol-5-yl]-propionic acid

2-[2-(3,4-dichloro-phenyl)-benzooxazol-5-yl]-propionic acid

2-(2-Amino-11-oxo-10,11-dihydro-dibenzo[b,f][1,4]oxazepin-8-yl)-propionic acid

Refernces

• 1、 -. "Process for preparing benzoxazolyl propionic acid derivatives". . . Retrieved 2008/06/13.